Power of cooperativity: Lewis acid-Lewis base bifunctional asymmetric catalysis
Power of cooperativity: Lewis acid-Lewis base bifunctional asymmetric catalysis
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DOI：
10.1055/s-2005-869831
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发表时间：
2005-06-17
期刊：
影响因子：
2
通讯作者：
Shibasaki, M
中科院分区：
文献类型：
--
作者：
Kanai, M;Kato, N;Shibasaki, M
双功能不对称催化的概念对于设计新型的不对称催化剂具有重要意义。我们描述了我们的调查开始的BINOL衍生的刘易斯酸-刘易斯碱双功能不对称催化剂的醛的氰基硅烷化的发展。概念的初步建立之后，发展了新的糖衍生催化剂，促进酮的一般催化对映选择性氰硅烷化。我们还描述了催化的吡啶衍生物的Reissert反应和酮亚胺的Strecker反应作为该领域的最新进展。1引言2刘易斯酸的一般概念-刘易斯碱双功能不对称催化3醛和醛亚胺的催化对映选择性硅腈化4喹啉和异喹啉的催化对映选择性Reissert反应5吡啶衍生物的催化对映选择性Reissert反应6四取代碳不对称催化中的结构挑战7酮的催化对映选择性氰基硅烷化8酮亚胺的催化对映选择性Strecker反应9总结。
The concept of bifunctional asymmetric catalysis is very powerful for designing new enantioselective catalysts. We describe our investigation starting with the development of a BINOL-derived Lewis acid-Lewis base bifunctional asymmetric catalyst for cyanosilylation of aldehydes. The initial establishment of the concept was followed by the development of new sugar-derived catalysts that promote general catalytic enantioselective cyanosilylation of ketones. We also describe the catalytic enantioselective Reissert reaction of pyridine derivatives and Strecker reaction of ketoimines as recent advances in this field.1 Introduction2 General Concept of Lewis Acid-Lewis Base Bifunctional Asymmetric Catalysis3 Catalytic Enantioselective Cyanosilylation of Aldehydes and Aldimines4 Catalytic Enantio selective Reissert Reaction of Quinolines and Isoquinolines5 Catalytic Enantioselective Reissert Reaction of Pyridine Derivatives6 Tetrasubstituted Carbon Construction as a Challenge in Asymmetric Catalysis7 Catalytic Enantioselective Cyanosilylation of Ketones8 Catalytic Enantioselective Strecker Reaction of Ketoimines9 Summary.