Auditory conflict and congruence in frontotemporal dementia
Auditory conflict and congruence in frontotemporal dementia
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DOI：
10.1016/j.neuropsychologia.2017.08.009
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发表时间：
2017-09-01
期刊：
影响因子：
2.6
通讯作者：
Warren, Jason D.
中科院分区：
文献类型：
--
作者：
Clark, Camilla N.;Nicholas, Jennifer M.;Warren, Jason D.
信号冲突和一致性的分析受损可能导致额颞叶痴呆患者出现各种社会情绪症状，但其潜在机制尚未确定。在这里，我们解决了这个问题的患者行为变异型额颞叶痴呆（bvFTD; n = 19）和语义痴呆（SD; n = 10）相对于健康的老年人（n = 20）。我们创建了听觉场景，其中语义和情感的一致性成分的声音独立探测;相关的任务控制听觉感知相似性，场景解析和语义能力。听觉一致性处理的神经解剖学相关性进行了评估，使用基于体素的形态测量。与健康对照组相比，bvFTD和SD组的语义和情感一致性处理受损（考虑听觉控制任务表现后），声音与场景的情感整合减少。听觉语义一致性处理的灰质相关的分布区域包括前额叶，顶叶颞叶和岛区和听觉情感一致性的相关部分重叠的时间，岛和纹状体区域。我们的研究结果表明，听觉信号相关性的解码可能会探讨一个通用的认知机制和神经结构的基础额颞叶痴呆综合征。
Impaired analysis of signal conflict and congruence may contribute to diverse socio-emotional symptoms in frontotemporal dementias, however the underlying mechanisms have not been defined. Here we addressed this issue in patients with behavioural variant frontotemporal dementia (bvFTD; n = 19) and semantic dementia (SD; n = 10) relative to healthy older individuals (n = 20). We created auditory scenes in which semantic and emotional congruity of constituent sounds were independently probed; associated tasks controlled for auditory perceptual similarity, scene parsing and semantic competence. Neuroanatomical correlates of auditory congruity processing were assessed using voxel-based morphometry. Relative to healthy controls, both the bvFTD and SD groups had impaired semantic and emotional congruity processing (after taking auditory control task performance into account) and reduced affective integration of sounds into scenes. Grey matter correlates of auditory semantic congruity processing were identified in distributed regions encompassing prefrontal, parieto-temporal and insular areas and correlates of auditory emotional congruity in partly overlapping temporal, insular and striatal regions. Our findings suggest that decoding of auditory signal relatedness may probe a generic cognitive mechanism and neural architecture underpinning frontotemporal dementia syndromes.