Genetics of gliding motility and development in Myxococcus xanthus.
Genetics of gliding motility and development in Myxococcus xanthus.
复制标题
黄色粘球菌滑动运动和发育的遗传学。
DOI：
10.1007/bf02529977
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发表时间：
1995
影响因子：
2.8
通讯作者：
Youderian,P
中科院分区：
文献类型：
--
作者：
Hartzell,PL;Youderian,P
多细胞真核生物的成功发育需要细胞间的通讯以及协调的空间和时间运动。使真核生物的发育成熟所需的复杂网络阵列可以由更简单的原核生物黄色粘球菌的发育来模拟。作为其生命周期的一部分，M。黄曲霉形成含有分化细胞的多细胞子实体。对M.黄曲霉菌的发育是可能的，因为具有阻止发育的突变的菌株可以保持在营养状态。在M.由饥饿引起的黄变和发育中的早期事件表明，信号传导阶段已经进化为监测发育细胞的代谢状态。在缺乏这些信号（包括氨基酸、α-酮酸和其他中间代谢物）的情况下，细胞分化为粘孢子的能力受损。阻止控制滑行、运动的基因的突变以令人惊讶的方式破坏子实体的形态发生和孢子发生。在这篇综述中，我们提出的数据，鼓励未来的遗传和生化研究之间的关系的运动，细胞-细胞信号，和发展inM。xanthus
Successful development in multicellular eukaryotes requires cell-cell communication and the coordinated spatial and temporal movements of cells. The complex array of networks required to bring eukaryotic development to fruition can be modeled by the development of the simpler prokaryoteMyxococcus xanthus. As part of its life cycle,M. xanthusforms multicellular fruiting bodies containing differentiated cells. Analysis of the genes essential forM. xanthusdevelopment is possible because strains with mutations that block development can be maintained in the vegetative state. Development inM. xanthusis induced by starvation, and early events in development suggest that signaling, stages have evolved to monitor the metabolic state of the developing cell. In the absence of these signals, which include amino acids, α-keto acids, and other intermediary metabolites, the ability of cells to differentiate into myxospores is impaired. Mutations that block genes controlling gliding, motility disrupt the morphogenesis of fruiting bodies and sporogenesis in surprising ways. In this review, we present data that encourage future genetic and biochemical studies of the relationships between motility, cell-cell signaling, and development inM. xanthus.