Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance
Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance
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DOI：
10.1016/j.ejca.2008.04.020
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发表时间：
2008-07-01
影响因子：
8.4
通讯作者：
Ellis, Ian O.
中科院分区：
文献类型：
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作者：
Habashy, Hany Onsy;Powe, Desmond G.;Ellis, Ian O.
叉头盒A1(FOXA1)控制雌激素受体(ER)调控基因的下游转录。在这项研究中，用免疫组织化学方法评估了FOXA1在一系列具有良好特征的大型浸润性乳腺癌中的生物学和预后价值，并使用组织芯片进行了长期随访。FOXA1的表达与激素受体(ERα、PGR和AR)、肿瘤体积较小、组织学分级较低、腔内细胞角蛋白(CK18和CK7/8)、BRCA1和E-钙粘素有关。其表达与基础CKS(CK14和CK5/6)及P-钙粘素呈负相关。然而，我们发现FOXA1的高表达与整个系列中较好的生存有关；多因素分析表明FOXA1不是一个独立的预后标志物。总之，我们的结果表明FOXA1蛋白与良好预后的标志物相关，支持其在乳腺癌中作为生长抑制因子的作用。在本系列中，FOXA1被发现对乳腺癌没有独立的预后意义，因此，在常规实践中，仅凭FOXA1的免疫组织化学评估似乎与将ER阳性(管腔样)肿瘤分成具有临床意义的亚组无关。(C)2008爱思唯尔有限公司。保留所有权利。
The forkhead-box A1 (FOXA1) controls downstream transcription of oestrogen receptor (ER)-regulated genes. In this study, the biological and prognostic value of FOXA1 expression was assessed immunohistochemically in a large and well-characterised series of invasive breast carcinoma with a long term follow-up using tissue microarray. FOXA1 expression was associated with steroid hormone receptors (ER alpha, PgR and AR), other variables of good prognosis such as smaller tumour size, lower histological grade, luminal cytokeratins (CK18 and CK7/8), BRCA1 and E-cadherin. Its expression showed an inverse relation with basal CKs (CK14 and CK5/6) and P-cadherin. We found an association between high FOXA1 expression and a better survival in the whole series however; multivariate analysis showed that FOXA1 was not an independent prognostic marker.In conclusion, our results show that FOXA1 protein is associated with markers of good prognosis supporting its role as a growth repressor in breast cancer. In this series, FOXA1 was found not to be of an independent prognostic significance in breast cancer and as such its immunohistochemical assessment alone does not appear to have relevance in routine practice to stratify ER-positive (luminal-like) tumours into clinically significant subgroups. (C) 2008 Elsevier Ltd. All rights reserved.