Microphase separation in nonequilibrium biomembranes.
Microphase separation in nonequilibrium biomembranes.
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非平衡生物膜中的微相分离。
DOI：
10.1103/physrevlett.106.238101
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发表时间：
2010
影响因子：
8.6
通讯作者：
M. S. Turner
中科院分区：
文献类型：
--
作者：
P. Sens;M. S. Turner
细胞膜组成的异质性被认为在许多生理过程中起着重要作用。我们研究了膜成分的变化是如何由非热波动力驱动的，因此显示了这些变化是如何在远离膜的任何临界点的地方发生的。我们表明，膜的稳态不仅由力的强度以及它们与膜的耦合方式控制，而且由它们的动力学控制：在一个简单的模型中，这是由单个力相关时间捕获的。我们得出的结论是，膜组成与正常机械力的耦合，例如可能由聚合细胞骨架丝施加的机械力，可能在控制细胞膜的稳定状态中发挥重要作用，在10-100 nm范围内，细胞膜的组成在长度尺度上表现出短暂的横向调制。
Compositional heterogeneities of cell membranes are thought to play an important role in many physiological processes. We study how variations in the membrane composition can be driven by nonthermal fluctuating forces and therefore show how these can occur relatively far from any critical point for the membrane. We show that the membrane steady state is not only controlled by the strength of the forces and how they couple to the membrane, but also by their dynamics: In a simple class of models this is captured by a single force correlation time. We conclude that the coupling of membrane composition to normal mechanical forces, such as might be exerted by polymerizing cytoskeleton filaments, could play an important role in controlling the steady state of a cell membrane that exhibits transient lateral modulations of its composition on length scales in the 10-100 nm regime.