T2-Weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE).
T2-Weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE).
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DOI：
10.1002/mrm.26152
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发表时间：
2017-02
影响因子：
3.3
通讯作者：
Jezzard P
中科院分区：
文献类型：
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作者：
Viessmann O;Li L;Benjamin P;Jezzard P
目的优化7T脑血管壁成像(VWI)，以获得清晰的管壁图像和高边界对比度。对可变翻转角涡轮自旋回波方案(SPACE)进行了优化。SPACE提供了黑血对比，但对脑脊液(CSF)的挤压作用较小。然而，用于定制激励(但丁)准备的延迟和章动交替抑制了来自每秒几毫米缓慢运动的自旋的信号。因此，我们为7T优化了但丁准备模块。计算11名志愿者大脑中动脉(MCA)的空间和Dante空间的信噪比(SNR)、对比噪声比(CNR)和管壁、脑脊液、管腔的信号比。采用Dante-SPACE对1例大脑中动脉狭窄患者进行扫描。7T优化的空间序列使血管壁点扩散函数提高了17%。与未准备好的间隙相比，Dante间隙扫描的CNR增加了一倍(12.2比5.6)。这种增加在右侧大脑半球显著(P = 0.016)，但在左侧(P = 0.090)。管壁和管腔之间的CNR降低了一半，但仍保持在较高水平(24.9比56.5)。优化后的空间序列改善了7T时的VWI。额外的但丁制剂增加了壁面和脑脊液之间的对比度。增加外部边界对比度是以降低内部边界对比度为代价的。Magn Reson Med 77：655-663,2017。《医学中的磁共振》作者由威利期刊公司代表国际医学磁共振学会出版。这是一篇在知识共享署名许可证条款下开放获取的文章，该许可证允许在任何媒体上使用、分发和复制，只要正确引用原始作品即可。
To optimize intracranial vessel wall imaging (VWI) at 7T for sharp wall depiction and high boundary contrast. A variable flip angle turbo spin echo scheme (SPACE) was optimized for VWI. SPACE provides black‐blood contrast, but has less crushing effect on cerebrospinal fluid (CSF). However, a delay alternating with nutation for tailored excitation (DANTE) preparation suppresses the signal from slowly moving spins of a few mm per second. Therefore, we optimized a DANTE‐preparation module for 7T. Signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR), and signal ratio for vessel wall, CSF, and lumen were calculated for SPACE and DANTE‐SPACE in 11 volunteers at the middle cerebral artery (MCA). An exemplar MCA stenosis patient was scanned with DANTE‐SPACE. The 7T‐optimized SPACE sequence improved the vessel wall point‐spread function by 17%. The CNR between the wall and CSF was doubled (12.2 versus 5.6) for the DANTE‐SPACE scans compared with the unprepared SPACE. This increase was significant in the right hemisphere (P = 0.016), but not in the left (P = 0.090). The CNR between wall and lumen was halved, but remained at a high value (24.9 versus 56.5). The optimized SPACE sequence improves VWI at 7T. Additional DANTE preparation increases the contrast between the wall and CSF. Increased outer boundary contrast comes at the cost of reduced inner boundary contrast. Magn Reson Med 77:655–663, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.