Effect of Maternal Age on Pregnancy or Neonatal Outcomes Among 4,958 Infertile Women Using a Freeze-All Strategy
Effect of Maternal Age on Pregnancy or Neonatal Outcomes Among 4,958 Infertile Women Using a Freeze-All Strategy
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使用全冻结策略研究母亲年龄对 4,958 名不孕妇女妊娠或新生儿结局的影响
DOI：
10.3389/fmed.2019.00316
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发表时间：
2020-01-10
影响因子：
3.9
通讯作者：
Wang, Yun
中科院分区：
文献类型：
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作者：
Lin, Jiaying;Huang, Jialyu;Wang, Yun
全冷冻策略在全球体外受精 (IVF) 周期中得到越来越多的采用，但这种方法的相对优势尚未完全了解。在此，我们试图评估母亲年龄如何影响接受冻融胚胎移植（FET）的女性的妊娠和新生儿结局。在这项回顾性分析中，我们评估了 2017 年 1 月至 12 月大学附属高等教育中心 4,958 名女性的结局。我们比较了对照组（<30 岁）和高龄产妇组（30-34 岁、35-37 岁、38-40 岁、41-43 岁和 44-50 岁）的妊娠和新生儿结局。我们发现，全冷冻策略后第一个 FET 周期的活产率 (LBR) 随着母亲年龄的增加而显着下降，其中 35-37 岁和 38-40 岁年龄组下降最明显（LBR：<30 岁为 51.12%，30-34 岁为 43.86%，35-37 岁为 41.64%，38-40 岁为 25.67%岁，40-43 岁分别为 15.58%，44-50 岁为 4.78%）。各研究组的早产率 (PTD)、严重 PTD、低出生体重 (LBW)、严重 LBW、足月 LBW、早产 LBW 和巨大儿的发生率具有可比性。因此，这些结果表明，在全冻结策略的背景下，增加产妇年龄会对妊娠结局产生不利影响，但不会影响 PTD 或 LBW 风险。
The freeze-all strategy has been increasingly employed in the context of in vitro fertilization (IVF) cycles globally, but the relative advantages of this approach are not entirely understood. Herein we sought to assess how maternal age affected pregnancy and neonatal outcomes in women who had undergone frozen–thawed embryo transfer (FET). In this retrospective analysis, we assessed outcomes for 4,958 total women at the University-affiliated Tertiary Centre from January—December 2017. We compared pregnancy and neonatal outcomes between a control group (<30 years old) and groups of more advanced maternal age (30–34, 35–37, 38–40, 41–43, and 44–50 years). We found that live birth rates (LBR) for the first FET cycle following a freeze-all strategy significantly declined with increasing maternal age, with the most pronounced declines in the 35–37 and 38–40 age groups (LBR: 51.12% at <30 years, 43.86% at 30–34 years, 41.64% at 35–37 years, 25.67% at 38–40 years, 15.58% at 40–43 years, and 4.78% at 44–50 years, respectively). Rates of preterm delivery (PTD), very PTD, low birth weight (LBW), very LBW, term LBW, preterm LBW, and macrosomia were comparable across study groups. Together these results thus suggest that increasing maternal age has an adverse impact on pregnancy outcomes without affecting PTD or LBW risk in the context of a freeze-all strategy.