Generation of DNA-free Escherichia coli cells by 2-aminopurine requires mismatch repair and nonmethylated DNA
Generation of DNA-free Escherichia coli cells by 2-aminopurine requires mismatch repair and nonmethylated DNA
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DOI：
10.1128/jb.188.1.339-342.2006
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Kohiyama, M
中科院分区：
文献类型：
--
作者：
Matic, I;Ekiert, D;Kohiyama, M
由碱基类似物2-氨基嘌呤的掺入引发的非定向错配修复通过DNA双链断裂杀死DNA甲基化缺陷的大肠杆菌dam细胞。随后，染色体DNA完全降解，导致无DNA细胞。
Undirected mismatch repair initiated by the incorporation of the base analog 2-aminopurine kills DNA-methylation-deficient Escherichia coli dam cells by DNA double-strand breakage. Subsequently, the chromosomal DNA is totally degraded, resulting in DNA-free cells.