CONTROL OF EMBRYONIC MOTONEURON SURVIVAL INVIVO BY CILIARY NEUROTROPHIC FACTOR
CONTROL OF EMBRYONIC MOTONEURON SURVIVAL INVIVO BY CILIARY NEUROTROPHIC FACTOR
复制标题
DOI：
10.1126/science.2011743
复制
发表时间：
1991-03-29
期刊：
影响因子：
56.9
通讯作者：
MACDONALD, J
中科院分区：
文献类型：
--
作者：
OPPENHEIM, RW;PREVETTE, D;MACDONALD, J
在神经系统的发育过程中，许多区域的神经元因增殖而过量产生，之后多余的细胞因细胞死亡而被消除。 在正常发育过程中，只有一部分神经元的存活被认为是受到神经营养剂的有限可用性的调节。 其中一种假定的营养剂是睫状神经营养因子（CNTF），它是一种在体外促进睫状神经元、感觉神经元和交感神经元存活的多肽。 然而，与体外研究的结果相反，每天用纯化的人重组CNTF对鸡胚进行体内处理未能挽救这些细胞群免于细胞死亡，而CNTF确实促进了脊髓运动神经元的体内存活。 因此，对于其在体外起作用的那些胚胎神经元（尤其是睫状神经元），CNTF在体内可能不充当神经营养剂。 相反，CNTF 可能是运动神经元体内存活所必需的。
During development of the nervous system, neurons in many regions are overproduced by proliferation, after which the excess cells are eliminated by cell death. The survival of only a proportion of neurons during normal development is thought to be regulated by the limited availability of neurotrophic agents. One such putative trophic agent is ciliary neurotrophic factor (CNTF), a polypeptide that promotes the survival of ciliary, sensory, and sympathetic neurons in vitro. In contrast to the results of in vitro studies, however, the daily treatment of chick embryos in vivo with purified human recombinant CNTF failed to rescue any of these cell populations from cell death, whereas CNTF did promote the in vivo survival of spinal motoneurons. Thus, CNTF may not act as a neurotrophic agent in vivo for those embryonic neurons (especially ciliary neurons) on which it acts in vitro. Rather, CNTF may be required for in vivo survival of motoneurons.