Multi-Dimensional Nanostructures for Microfluidic Screening of Biomarkers: From Molecular Separation to Cancer Cell Detection.
Multi-Dimensional Nanostructures for Microfluidic Screening of Biomarkers: From Molecular Separation to Cancer Cell Detection.
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DOI：
10.1007/s10439-015-1521-2
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发表时间：
2016-04
影响因子：
3.8
通讯作者：
Zhang JX
中科院分区：
文献类型：
--
作者：
Ng E;Chen K;Hang A;Syed A;Zhang JX
快速筛选具有高度特异性和准确性的生物标志物对于许多即时诊断至关重要。微流体技术，使用微尺度通道来操纵小的液体样品并进行平行反应，为解决生物学中的基本问题提供了巨大的机会，并为医学提供了一套快速增长的临床工具。新兴的多维纳米结构，当与微流体相结合时，能够以高特异性和灵敏度进行有效和高效的筛选，这两者都是生物检测系统的重要方面。在这篇综述中，我们提供了目前的研究和技术，利用纳米结构，以促进微流体通道中的生物分离的概述。各种重要的物理参数和理论方程，表征和管理纳米结构集成微流体通道中的流动将被介绍和讨论。多维纳米结构，包括纳米粒子，纳米柱，和纳米多孔层，与微流体通道集成在分子和细胞分离的应用也将进行审查。最后，我们将结束与纳米结构集成微流体平台的未来及其在生物和生物医学应用中的作用的见解。
Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a fast growing set of clinical tools for medicine. Emerging multi-dimensional nanostructures, when coupled with microfluidics, enable effective and efficient screening with high specificity and sensitivity, both of which are important aspects of biological detection systems. In this review, we provide an overview of current research and technologies that utilize nanostructures to facilitate biological separation in microfluidic channels. Various important physical parameters and theoretical equations that characterize and govern flow in nanostructure-integrated microfluidic channels will be introduced and discussed. The application of multi-dimensional nanostructures, including nanoparticles, nanopillars, and nanoporous layers, integrated with microfluidic channels in molecular and cellular separation will also be reviewed. Finally, we will close with insights on the future of nanostructure-integrated microfluidic platforms and their role in biological and biomedical applications.