Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target

Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target
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DOI：
10.1111/bph.13209
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发表时间：
2015-09
期刊：
British Journal of Pharmacology
影响因子：
7.3
通讯作者：
Xiao-Yi Zeng;Hao Wang;Fang Bai;Xiu Zhou;Songpei Li;Lu-ping Ren;Ruo-Qiong Sun;Charlie C. L. Xue-Charlie-C.-L.-Xu
Xiao-Yi Zeng;Hao Wang;Fang Bai;Xiu Zhou;Songpei Li;Lu-ping Ren;Ruo-Qiong Sun;Charlie C. L. Xue-Charlie-C.-L.-Xu
中科院分区：
医学2区
文献类型：
--
作者：
Xiao-Yi Zeng;Hao Wang;Fang Bai;Xiu Zhou;Songpei Li;Lu-ping Ren;Ruo-Qiong Sun;Charlie C. L. Xue-Charlie-C.-L.-Xu

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Matrine is a small molecule drug used in humans for the treatment of chronic viral infections and tumours in the liver with little adverse effects. The present study investigated its therapeutic efficacy for insulin resistance and hepatic steatosis in high‐fat‐fed mice.