Fasciola hepatica: influence of thymus function on the liver pathology in mice.
Fasciola hepatica: influence of thymus function on the liver pathology in mice.
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肝片形吸虫：胸腺功能对小鼠肝脏病理的影响。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
L. Eriksen
中科院分区：
文献类型：
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作者：
L. Eriksen
比较胸腺缺损（nu/nu）小鼠、胸腺增生（+/+）小鼠、（背景株为nu/nu小鼠）和胸腺重组（nu/nu小鼠）小鼠肝片吸虫感染的肝脏病理变化。在寄生虫在肝脏中的迁移过程中，胸腺缺乏导致无限制的肝脏损伤。在nu/nu小鼠中，很少有嗜酸性粒细胞和单核细胞浸润，大量出血和肝细胞坏死。门静脉反应和胆管增生均受到抑制。肝组织再生、实质纤维化和门周纤维化及浆细胞增殖减少。本文讨论了吸虫引起肝脏病理的可能的因果机制。提示胸腺依赖的细胞反应调节肝念珠菌引起的组织损伤。
Liver pathology during experimental Fasciola hepatica infection was compared in thymus-deficient (nu/nu) mice and in thymus-bearing (+/+) mice, (back ground strain to nu/nu mice) and thymus-reconstituted nu/nu mice. Thymus deficiency resulted in unrestricted liver damage during the migration of the parasite in the liver. In nu/nu mice the migratory tracks were infiltrated by very few eosinophils and mononuclear cells, haemorrhages and liver cell necroses were extensive. Portal area reaction and bile duct hyperplasia were depressed. Regeneration of liver tissue, parenchymal and periportal fibrosis and plasma cell proliferation were reduced. The possible causal mechanisms involved in fluke induced liver pathology are discussed. It is suggested that a thymus-dependent cellular reaction modulates the tissue damage produced by F. hepatica.