Orbitofrontal morphology in people at high risk of developing schizophrenia
Orbitofrontal morphology in people at high risk of developing schizophrenia
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DOI：
10.1016/j.eurpsy.2010.03.001
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发表时间：
2010-10-01
影响因子：
7.8
通讯作者：
McIntosh, A. M.
中科院分区：
文献类型：
--
作者：
Chakirova, G.;Welch, K. A.;McIntosh, A. M.
背景- 眶额皮质（OFC）沟回模式的消失在精神分裂症中已有报道，但尚不清楚这些是否早于精神病。- 对146例精神分裂症高危人群、34例首发精神分裂症患者和36例健康对照者进行了扫描和临床评估。利用Chiavaras提出的分类系统，我们对OFC模式进行了分类，并比较了各组之间的分布，以及那些高危受试者之间的分布，并没有发展成精神分裂症。探讨OFC分型与高危人群中OFC分型的关系。- 我们完善了Chiavaras的分类系统，确定了以前未报道的OFC表面结构的变体。OFC模式在精神分裂症高危组与非精神分裂症高危组、首发精神分裂症组与健康对照组之间的分布差异有统计学意义。在高危人群中，OFC III型与精神分裂症结构化量表（SIS）精神病因子的较高评分相关。- 我们的研究结果表明，OFC III型与精神分裂症发生前的精神病特征有关。OFC形态学的特征可能在识别那些最有可能发展为精神分裂症的人中发挥作用。(C)2010年Elsevier Masson SAS。All rights reserved.
Background. - Abnormalities of orbitofrontal cortex (OFC) sulcogyral patterns have been reported in schizophrenia, but it is not known if these predate psychosis.Methods. - Hundred and forty-six subjects at high genetic risk of schizophrenia, 34 first episode of schizophrenia patients (SZ) and 36 healthy controls were scanned and clinically assessed. Utilising the classification system proposed by Chiavaras, we categorised OFC patterns and compared their distribution between the groups, as well as between those high risk subjects who did, and did not develop schizophrenia. The relationship between OFC pattern and schizotypy was explored in high risk subjects.Results. - We refined Chiavaras' classification system, with the identification of a previously unreported variant of OFC surface structure. There were significant differences in distribution of OFC patterns between high risk subjects who did or did not develop schizophrenia as well as between the first episode of schizophrenia group and healthy controls. Within the high risk group, possession of OFC Type III was associated with higher ratings on the Structured Inventory for Schizotypy (SIS) psychotic factor.Conclusions. - Our results suggest that OFC Type III is associated with psychotic features before the development of schizophrenia. Characterisation of OFC morphology may have a role in the identification of those at greatest risk of developing schizophrenia. (C) 2010 Elsevier Masson SAS. All rights reserved.