Breakpoint map of human translocation cell cultures available from the NIGMS human genetic mutant cell repository.
Breakpoint map of human translocation cell cultures available from the NIGMS human genetic mutant cell repository.
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可从 NIGMS 人类遗传突变细胞存储库获取人类易位细胞培养物的断点图。
DOI：
10.1159/000131607
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Coriell,LL
中科院分区：
文献类型：
--
作者：
Aronson,MM;Miller,RC;Nichols,WW;Mulivor,RA;Greene,AE;Coriell,LL
美国国家普通医学科学研究所(NIGMS)的人类遗传突变细胞报告于1972年在新泽西州卡姆登的医学研究所(IMR)建立。这份报告包含了近3000个细胞系，这些细胞系来自具有明确突变条件的个体以及明显正常的个体。这个收集包括大约400个染色体异常的细胞系，其特征是染色体元素的转位、缺失、倒位、插入、环形成或非整倍体。具有染色体重排，特别是缺失和易位的细胞系的主要用途一直是基因剂量和定位研究。含有易位的细胞系在通过体细胞杂交来提高基因定位的分辨率方面变得特别有用。从它们的连锁群中分离出的染色体片段是通过易位原.
The Human Genetic Mutant Cell Repos itory of the National Institute of General Medical Sciences (NIGMS) was established in 1972 at the Institute for Medical Research (IMR) in Camden, New Jersey. The repos itory contains nearly 3,000 cell lines derived from individuals with defined mutant con ditions as well as from apparently normal individuals. This collection includes approx imately 400 cell lines which are chromosomally aberrant, characterized by trans location, deletion, inversion, insertion, ring formation, or aneuploidy of the chromo somal elements. The principal uses of the cell lines with chromosomal rearrangements, particularly deletions and translocations, have been gene dosage and mapping studies. Cell lines containing translocations have become particularly useful in increasing the resolu tion of gene mapping by somatic cell hybrid ization. Chromosome segments isolated from their linkage groups by translocation pro-