The Acute Exposure Guideline Level (AEGL) program: Applications of physiologically based pharmacokinetic modeling
The Acute Exposure Guideline Level (AEGL) program: Applications of physiologically based pharmacokinetic modeling
复制标题
DOI：
10.1080/15287390490428017
复制
发表时间：
2004-04-23
影响因子：
2.6
通讯作者：
Fisher, JW
中科院分区：
文献类型：
--
作者：
Bruckner, JV;Keys, DA;Fisher, JW
急性暴露指导水平（AEGL）计划的主要目的是为一生一次或罕见的高优先级危险化学品急性吸入暴露制定科学可信的限值。该方案的制定是因为社区需要有关危险化学品的信息，以协助应急规划、通知和反应，以及培训应急人员。AEGL适用于一般人群，包括儿童、老年人和其他潜在易感亚群。AEGL是空气中的化学品浓度，超过该浓度，人可能会感到明显的不适或刺激（AEGL-1）;严重，持久的健康影响（AEGL-2）;和危及生命的影响或死亡（AEGL-3）。测定五个暴露期（10和30分钟以及1、4和8小时）的AEGL。基于生理学的药代动力学（PBPK）模型在这里经常需要的物种间和时间尺度方面非常有用。PBPK模型用于当前的文章来预测三氯乙烯（TCE）的AEGLs，基于TCE在大鼠和人类的血液和/或大脑中的时间过程。这些AEGLs的标准时间尺度方法获得的值进行比较。AEGL国家咨询委员会是一个由联邦、州和地方政府机构以及工业和私营部门组织的代表组成的小组，负责编写正在审议的每种化学品的全面毒性评估文件。这些文件是根据国家研究理事会（NRC）指导方针制定的，在成为最终版本之前，必须由NRC急性暴露指导水平小组委员会进行审查。目前已公布了18种化学品的《环境影响评价清单》，预计每年将对40至50种化学品进行评价。
The primary aim of the Acute Exposure Guideline Level (AEGL) program is to develop scientifically credible limits for once-in-a-lifetime or rare acute inhalation exposures to high-priority, hazardous chemicals. The program was developed because of the need of communities for information on hazardous chemicals to assist in emergency planning, notification, and response, as well as the training of emergency response personnel. AEGLs are applicable to the general population, including children, the elderly, and other potentially susceptible subpopulations. AEGLs are the airborne concentrations of chemicals above which a person could experience notable discomfort or irritation (AEGL-1); serious, long-lasting health effects (AEGL-2); and life-threatening effects or death (AEGL-3). AEGLs are determined for five exposure periods (10 and 30 min and 1, 4, and 8 h). Physiologically based pharmacokinetic (PBPK) models can be very useful in the interspecies and time scaling often required here. PBPK models are used for the current article to predict AEGLs for trichloroethylene (TCE), based on the time course of TCE in the blood and/or brain of rats and humans. These AEGLs are compared to values obtained by standard time-scaling methods. Comprehensive toxicity assessment documents for each chemical under consideration are prepared by the National Advisory Committee for AEGLs, a panel comprised of representatives of federal, state, and local governmental agencies, as well as industry and private-sector organizations. The documents are developed according to National Research Council (NRC) guidelines and must be reviewed by the NRC Subcommittee on Acute Exposure Guideline Levels before becoming final. AEGLs for 18 chemicals have been published, and it is anticipated that 40 to 50 chemicals will be evaluated annually.