Immunobiology of liver xenotransplantation.
Immunobiology of liver xenotransplantation.
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DOI：
10.1586/eci.12.56
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发表时间：
2012-09
影响因子：
4.4
通讯作者：
Cooper DK
中科院分区：
文献类型：
--
作者：
Ekser B;Burlak C;Waldman JP;Lutz AJ;Paris LL;Veroux M;Robson SC;Rees MA;Ayares D;Gridelli B;Tector AJ;Cooper DK
猪是未来器官异种移植的首选物种。随着转基因猪的发展，临床异种移植越来越接近现实。在临床前研究（猪-非人灵长类动物）中，异种移植人CD 55转基因猪或α 1，3-半乳糖基转移酶基因敲除+/−人CD 46转基因猪的肝脏，存活期约为7-9天。虽然肝功能，包括凝血功能，已被证明是令人满意的，血小板减少症的立即发展是非常有限的猪肝异种移植，即使作为一个“桥梁”同种异体移植。目前的研究旨在了解血小板活化，聚集和吞噬作用的免疫生物学，特别是血小板与肝窦内皮细胞，肝细胞和枯否细胞之间的相互作用，以确定可能使临床应用的干预措施。
Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD55 or from α1,3-galactosyltransferase gene-knockout pigs+/− transgenic for human CD46, is associated with survival of approximately 7–9 days. Although hepatic function, including coagulation, has proved to be satisfactory, the immediate development of thrombocytopenia is very limiting for pig liver xenotransplantation even as a ‘bridge’ to allotransplantation. Current studies are directed to understand the immunobiology of platelet activation, aggregation and phagocytosis, in particular the interaction between platelets and liver sinusoidal endothelial cells, hepatocytes and Kupffer cells, toward identifying interventions that may enable clinical application.
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影响因子：
3.9
作者：
Cooper DK;Ekser B;Burlak C;Ezzelarab M;Hara H;Paris L;Tector AJ;Phelps C;Azimzadeh AM;Ayares D;Robson SC;Pierson RN 3rd
通讯作者：
Pierson RN 3rd
影响因子：
15.9
作者：
Dwyer, KM;Robson, SC;d'Apice, AJF
通讯作者：
d'Apice, AJF
影响因子：
3.9
作者：
Burlak, Christopher;Paris, Leela L.;Tector, A. Joseph
通讯作者：
Tector, A. Joseph
影响因子：
6.2
作者：
Chihara, Ray K.;Paris, Leela L.;Burlak, Christopher
通讯作者：
Burlak, Christopher
影响因子：
3.9
作者：
Burlak, Christopher;Wang, Zheng-Yu;Tector, A. Joseph
通讯作者：
Tector, A. Joseph