EFFECT OF BETAMETHASONE AND EXERCISE ON EQUINE CARPAL JOINTS WITH OSTEOCHONDRAL FRAGMENTS
EFFECT OF BETAMETHASONE AND EXERCISE ON EQUINE CARPAL JOINTS WITH OSTEOCHONDRAL FRAGMENTS
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DOI：
10.1111/j.1532-950x.1994.tb00497.x
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发表时间：
1994-09-01
影响因子：
1.8
通讯作者：
LAMAR, CH
中科院分区：
文献类型：
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作者：
FOLAND, JW;MCILWRAITH, CW;LAMAR, CH
在12匹马的桡骨腕骨远端关节镜下创建骨软骨碎片。在手术后第14天，每匹马的一个中腕关节注射2.5 mL Betavet Soluspan（每毫升3.9 mg betavet磷酸钠和12 mg醋酸β-米松），对侧关节注射2.5 mL生理盐水作为对照。在第35天重复关节内治疗。在第17天，六匹马开始在高速跑步机上每周锻炼5天。在整个研究期间，将其他6匹马饲养在箱式畜栏中，作为未运动对照。在第56天，对所有马进行临床和放射学检查，然后人道处死。获取样本进行组织学、组织化学和生物化学评价。第56天，在6匹运动马中的5匹中观察到轻度跛行; 4匹马的对照肢体跛行，1匹马的给药肢体跛行。在评价跛行的5匹未运动马中，2匹对照肢体跛行，2匹治疗肢体跛行，1匹对照和治疗肢体均跛行。类固醇治疗肢体与对照肢体的X线片或触诊无差异。除了三个关节外，所有关节的骨软骨碎片都牢固地重新附着在桡骨腕骨上。大体软骨损伤在类固醇治疗的关节和注射生理盐水的关节之间没有差异。在组织学上，无论是否运动，β-米松都没有显著的有害影响，但在治疗的关节中有更多病理变化的趋势。有一个趋势，减少糖胺聚糖染色类固醇治疗的关节休息的马，而行使的马有相似的糖胺聚糖染色治疗和对照关节。处理组和对照组关节的含水量或糖醛酸浓度无显著差异。在该腕部芯片模型中，关节内betalone给药与休息或运动的马中的任何显著有害作用无关。(C)版权所有1994年由美国兽医学会
Osteochondral fragments were created arthroscopically on the distal aspect of both radial carpal bones in 12 horses. On day 14 after surgery, one middle carpal joint of each horse was injected with 2.5 mL Betavet Soluspan (3.9 mg betamethasone sodium phosphate and 12 mg beta-methasone acetate per milliliter) and the contralateral joint was injected with 2.5 mL saline as a control. Intra-articular treatments were repeated on day 35. On day 17, six horses began exercising 5 days per week on a high-speed treadmill. The other six horses were kept in box stalls throughout the study as nonexercised controls. On day 56, all horses were examined clinically and radiographically and then were euthanatized. Samples were obtained for histological, histochemical, and biochemical evaluation. Mild lameness was observed in five of the six exercised horses at day 56; four horses were lame in the control limb and one horse was lame in the treated limb. Of the five nonexercised horses evaluated for lameness, two were lame in the control limb, two were lame in the treated limb, and one was lame in both the control and the treated limb. No differences were noted on radiographs or palpation of steroid treated limbs versus control limbs. Firm reattachment of the osteochondral fragment to the radial carpal bone occurred in all but three joints. Gross cartilage damage was not different between steroid-treated joints and joints injected with saline. Histologically, there were no significant detrimental effects of beta-methasone with or without exercise, but there was a tendency for more pathological change in treated joints. There was a trend toward decreased glycosaminoglycan staining in steroid treated joints of rested horses, whereas exercised horses had similar glycosaminoglycan staining in treated and control joints. No significant difference in the water content or uronic acid concentration was detected between treated and control joints. Intra-articular betamethasone administration in this carpal chip model was not associated with any significant detrimental effects in either rested or exercised horses. (C) Copyright 1994 by The American College of Veterinary Surgeons