Polymorphisms in TRAIL predict long-term survival and extrahepatic recurrence following initial hepatectomy for hepatocellular carcinoma
Polymorphisms in TRAIL predict long-term survival and extrahepatic recurrence following initial hepatectomy for hepatocellular carcinoma
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DOI：
10.1002/jhbp.573
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发表时间：
2018-08-01
影响因子：
3
通讯作者：
Ohdan, Hideki
中科院分区：
文献类型：
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作者：
Imaoka, Yuki;Ohira, Masahiro;Ohdan, Hideki
背景肝脏自然杀伤细胞（NK）是最早对感染和恶性肿瘤（如术中肿瘤溢出）作出反应的细胞。肝脏NK细胞表达肿瘤坏死因子相关凋亡诱导配体（TRAIL），这是肝细胞癌（HCC）的标志物。然而，TRAIL单核苷酸多态性（SNPs）对肝切除术患者HCC的影响仍然不清楚。MethodsHere，我们研究了TRAIL SNPs（rs1131568，rs1131579和rs1131580）位于TNFSF 10基因外显子5的位置1525，1588和1595。共分析了104例接受初次肝切除术的HCC患者。Kaplan-Meier生存分析和考克斯比例风险回归分析进行评估TRAIL基因型和临床HCC outcomes.ResultsHaving的TRAIL SNP rs1131568和rs1131579的纯合子AA基因型和TRAIL SNP rs1131580的TT基因型患者的总生存率较低，肝外复发率较高（EHR）。而不是携带野生型或杂合基因型的患者。此外，单变量和多变量考克斯回归分析显示，目标TRAILSNP的纯合基因型是原发性肝癌初次肝切除术后EHR的独立预测因素。结论我们的研究结果表明，TRAILSNP的纯合基因型是原发性肝癌初次肝切除术患者EHR的独立预测因素。
BackgroundLiver natural killer (NK) cells are the first cells to respond to infections and malignancies, such as intraoperative tumor spill. Liver NK cells express tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a marker for hepatocellular carcinoma (HCC). However, the influence of TRAIL single-nucleotide polymorphisms (SNPs) on hepatectomy patients with HCC remains unclear.MethodsHere, we investigated TRAIL SNPs (rs1131568, rs1131579, and rs1131580) located at positions 1525, 1588, and 1595 of exon 5 of the TNFSF10 gene. A total of 104 HCC patients who underwent initial hepatectomy were analyzed. Kaplan-Meier survival analysis and Cox proportional hazard regression were conducted to evaluate the associations between TRAIL genotypes and clinical HCC outcomes.ResultsPatients harboring the homozygous AA genotype of TRAIL SNPs rs1131568 and rs1131579 and the TT genotype of the TRAIL SNP rs1131580 had lower overall survival and higher rates of extrahepatic recurrence (EHR) than patients harboring the wild type or heterozygous genotypes. Moreover, univariate and multivariate Cox regression analysis revealed that the homozygous genotypes of the target TRAIL SNPs were independent predictive factors for EHR after initial hepatectomy for HCC.ConclusionOur findings revealed that the homozygous genotypes of TRAIL SNPs are independent predictors of EHR in initial hepatectomy patients with HCC.