Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2-Aminopyridines as an Expedient Route to Imidazo[1,2-a]pyridines
Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2-Aminopyridines as an Expedient Route to Imidazo[1,2-a]pyridines
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DOI：
10.1002/ejoc.201101053
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发表时间：
2011-12-01
影响因子：
2.8
通讯作者：
Lin, Guo-qiang
中科院分区：
文献类型：
--
作者：
Liu, Ping;Deng, Chun-Lin;Lin, Guo-qiang
A new tandem route leading to imidazo[1,2-a]pyridines has been explored through the direct amination of aryl propargylic alcohols with 2-aminopyridines and their subsequent intramolecular cycloisomerization. A ZnCl2/CuCl system has been developed to promote this transformation, which resulted in various imidazo[1,2-a]pyridines in moderate to good yields.
