Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?
Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?
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DOI：
10.1101/gad.2054311
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发表时间：
2011-05-15
影响因子：
10.5
通讯作者：
Tapscott, Stephen J.
中科院分区：
文献类型：
--
作者：
Conerly, Melissa L.;MacQuarrie, Kyle L.;Tapscott, Stephen J.
已知染色质修饰酶是胚胎干细胞正确分化为特定谱系（例如神经元）的关键成分。最近，人们研究了 Polycomb 族蛋白在肌肉干细胞的规范和分化中的作用。从这个角度来看，我们回顾了 Juan 及其同事最近在《Genes & Development》（第 789-794 页）中关于多梳蛋白 Ezh2 在肌肉干细胞中的作用的研究，并讨论了一般谱系限制的影响。
Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.