PROSTACYCLIN PRODUCTION INCREASES DURING HUMAN PARTURITION
PROSTACYCLIN PRODUCTION INCREASES DURING HUMAN PARTURITION
复制标题
人类分娩期间前列环素的产生增加
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
L. Viinikka
中科院分区：
文献类型：
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作者：
O. Ylikorkala;L. Mäkäräinen;L. Viinikka
通过测定9名女性足月分娩前、分娩中和分娩后血浆中前列环素（PGI 2）的主要代谢产物6-酮-前列腺素F1 α（6-keto-prostaglandin F1 α）浓度以及分娩后脐动脉和静脉血浆中PGI 2的浓度，研究了PGI 2在人类分娩中的作用。6-keto-PGF 1 α的平均水平在分娩过程中显著升高。分娩前的平均水平为266 pg/ml，有规律宫缩时为341 pg/ml，宫颈扩张5 cm时为387 pg/ml，分娩时为386 pg/ml，胎盘排出时为397 pg/ml。分娩后2小时内，6-keto-PGF 1 α浓度降至低于分娩前水平233 pg/ml，并在产后前4天保持该水平。脐动脉和静脉血浆中6-keto-PGF 1 α的平均水平分别为1667和1193 pg/ml，显著高于母体血浆水平，但动脉和静脉水平之间无显著差异。PGI 2的特点是它的抗聚集和血管扩张能力，因此，在生产过程中的PGI 2的上升可能发挥作用，在产妇和子宫胎盘循环的分娩期血栓栓塞并发症的预防。
The role of prostacyclin (PGI2) in human parturition was studied by measuring the concentrations of its main metabolite, 6‐keto‐prostaglandin Flα, before, during and after term labour in the plasma of 9 women and after delivery in umbilical artery and vein plasma. The mean level of 6‐keto‐PGF1α rose significantly over the course of labour. The mean level was 266 pg/ml before labour, 341 pg/ml in the presence of regular contraction, 387 pg/ml at a cervical dilatation of 5 cm, 386 pg/ml at delivery, and 397 pg/ml at the expulsion of the placenta. The 6‐keto‐PGF1α concentration dropped to below pre‐labour levels of 233 pg/ml within 2 hours of delivery, and this level was maintained for the first four postpartum days. The mean levels of 6‐keto‐PGF1α in the umbilical artery and vein plasma, 1667 and 1193 pg/ml respectively, were significantly higher than the maternal plasma levels, but there was no significant difference between the artery and vein levels. PGI2 is characterized by its antiaggregatory and vasodilating abilities, so that the rise in PGI2 during labour may play a role in the prevention of intrapartum thromboembolic complications in the maternal and the uteroplacental circulation.