Non-competitive regulation of phencyclidine/σ-receptors by the N-methyl-d-aspartate receptor antagonist d-(−)-2-amino-5-phosphonovaleric acid
Non-competitive regulation of phencyclidine/σ-receptors by the N-methyl-d-aspartate
receptor antagonist d-(−)-2-amino-5-phosphonovaleric acid
复制标题
N-甲基-d-天冬氨酸受体拮抗剂 d-(−)-2-氨基-5-磷酸戊酸对苯环己哌啶/σ-受体的非竞争性调节
DOI：
10.1016/0304-3940(87)90632-x
复制
发表时间：
1987
影响因子：
2.5
通讯作者：
S. Zukin
中科院分区：
文献类型：
--
作者：
D. Javitt;A. Jotkowitz;R. Sircar;S. Zukin
Abstract d-(−)-2-Amino-5-phosphonovaleric acid (d (−) AP5), a selective, potent competitive antagonist of N-methyl-d-aspartate (NMDA)-type excitatory amino acid receptors was used to investigate the relationship between NMDA receptors and phencyclidine (PCP) binding. Incubation of rat brain membranes with d (−) AP5 decreased the apparent number of PCP/σ-receptors in dose-dependent fashion without affecting their affinity for [2-thienyl-3 H] cyclohexylpiperidine (TCP). These data, taken together with electrophysiological evidence that PCP non-competitively antagonizes NMDA receptor-mediated transmission, are consistent with the hypothesis that the PCP/σ-receptor may be situated in or near a channel regulated by an NMDA receptor complex.
苯环己哌啶类药物抑制大鼠纹状体中兴奋性氨基酸诱导的神经递质释放的表征。
DOI：
--
发表时间：
1986
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Snell,LD;Johnson,KM
通讯作者：
Johnson,KM
[3H]TCP 结合定位与 NMDA 受体之间高度相关。
影响因子：
5
作者：
Maragos,WF;Chu,DC;Greenamyre,JT;Penney,JB;Young,AB
通讯作者：
Young,AB