Human papillomavirus type 16/18 oncoproteins: potential therapeutic targets in non-smoking associated lung cancer.
Human papillomavirus type 16/18 oncoproteins: potential therapeutic targets in non-smoking associated lung cancer.
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DOI：
10.7314/apjcp.2012.13.11.5363
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发表时间：
2012-11
期刊：
影响因子：
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通讯作者：
E. Zhang;Xujie Tang
中科院分区：
文献类型：
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作者：
E. Zhang;Xujie Tang
高危型人乳头瘤病毒（HPV），尤其是HPV-16和HPV-18型被认为是亚洲非吸烟相关肺癌的重要危险因素。越来越多的证据表明，HPV癌蛋白可能有助于肺肿瘤的发生和细胞转化。重要的是，HPV 16/18 E6和E7癌蛋白可介导多种靶基因和蛋白的表达，如p53/pRb、VEGF、HIF-1α、cIAP-2和hTERT，并通过不同的信号通路促进肺癌细胞增殖、血管生成和细胞永生化。本文综述了HPV相关性肺癌的实验资料，描述了HPV E6/E7癌蛋白作用的主要靶点，并进一步讨论了HPV E6/E7癌蛋白参与的潜在信号通路。此外，我们还对HPV相关肺癌研究中存在的问题提出了质疑。
High-risk human papillomavirus (HPV) especially HPV-16 and HPV-18 types are speculated to be important risk factors in non-smoking associated lung cancer in Asia. Increasing evidence has demonstrated that HPV oncoproteins may contribute to lung tumorigenesis and cell transformation. Importantly, HPV 16/18 E6 and E7 oncoproteins can mediate expression of multiple target genes and proteins, such as p53/pRb, VEGF, HIF-1α, cIAP-2, and hTERT, and contribute to cell proliferation, angiogenesis and cell immortalization through different signaling pathways in lung cancer. This article provides an overview of experiment data on HPV-associated lung cancer, describes the main targets on which HPV E6/E7 oncoproteins act, and further discusses the potential signaling pathways in which HPV E6/E7 oncoproteins are involved. In addition, we also raise questions regarding existing problems with the study of HPV-associated lung cancer.