Representation of the temporal order of visual objects in the primate lateral prefrontal cortex.
Representation of the temporal order of visual objects in the primate lateral prefrontal cortex.
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DOI：
10.1152/jn.00647.2002
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发表时间：
2003-05
影响因子：
2.5
通讯作者：
Yoshihisa Ninokura;H. Mushiake;J. Tanji
中科院分区：
文献类型：
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作者：
Yoshihisa Ninokura;H. Mushiake;J. Tanji
回忆过去的情节涉及记住事件的时间顺序。我们研究了两只猴子的外侧前额皮质（PFC）的细胞活动，这些活动需要记住视觉对象出现的时间顺序，并在延迟后以相同的顺序到达每个对象。在这里，我们报告了侧前额皮质中的细胞活动，重点关注延迟期。我们发现 43% 的延迟期活动对于提示期视觉对象呈现的顺序是有选择性的。虽然大多数细胞活动对多个序列具有选择性，但一些细胞 (31%) 仅对六个序列之一具有选择性。我们的研究结果表明，当这些信息对于规划即将到来的运动行为是必要的时，PFC 细胞参与保存时间顺序信息。
Recollecting a past episode involves remembering the temporal order of events. We studied cellular activity in the lateral prefrontal cortex (PFC) of two monkeys that were required to remember the temporal order in which visual objects appeared and to reach for each object in the same order after a delay. Here, we report the cellular activity in the lateral PFC, focusing on the delay period. We found that 43% of the delay-period activity was selective for the sequence in which the visual objects were presented during the cue period. While the majority of cellular activity was selective for multiple sequences, some cells (31%) were selective for only one of six sequences. Our findings show that PFC cells are involved in holding temporal order information when that information is necessary for planning forthcoming motor behavior.