Blood flow velocity imaging of malignant melanoma by micro multipoint laser Doppler velocimetry
Blood flow velocity imaging of malignant melanoma by micro multipoint laser Doppler velocimetry
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DOI：
10.1063/1.3486678
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发表时间：
2010-09
影响因子：
4
通讯作者：
H. Ishida;T. Andoh;S. Akiguchi;H. Shirakawa;D. Kobayashi;Y. Kuraishi;T. Hachiga
中科院分区：
文献类型：
--
作者：
H. Ishida;T. Andoh;S. Akiguchi;H. Shirakawa;D. Kobayashi;Y. Kuraishi;T. Hachiga
我们研制了一种用于测量血流的激光多普勒测速仪--微型多点激光多普勒测速仪(μ-MLDV)。该设备可以测量绝对速度，并在此基础上显示血管的运动轨迹。在这项研究中，我们试图对移植到小鼠耳朵的恶性黑色素瘤进行血流速度成像。我们发现，起源于黑色素瘤的血管的血流速度远远大于正常皮肤的毛细血管的血流速度。此外，从血流速度图上可以清楚地看到肿瘤的形态。这些实验结果表明，μ-MLDV有可能作为鉴别良性黑色素瘤和恶性黑色素瘤的诊断方法。
We have developed a laser Doppler velocimeter to measure blood flow, the micromultipoint laser Doppler velocimeter (μ-MLDV). This equipment can measure absolute velocity and, based on this, can display the course of blood vessels. In this study, we attempted to perform blood flow velocity imaging of malignant melanoma transplanted to the mouse ear. We found that blood flow velocity of the formed blood vessels originating in the melanoma was much greater than that of the capillary vessels in normal skin. Furthermore, the form of the tumor was clearly visible from the blood flow velocity image. These experimental results suggest that μ-MLDV has potential as a diagnostic method for distinguishing benign nevi from malignant melanomas.