Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues.
Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues.
复制标题
c-kit 蛋白在人类实体瘤以及相应的胎儿和成人正常组织中的表达。
作者：
R. Matsuda;Takashi Takahashi;S. Nakamura;Y. Sekido;Keiko Nishida;Masao Seto;Tsutomu Seito;Takahiko Sugiura;Y. Ariyoshi;Toshitada Takahashi;R. Ueda
原癌基因c-kit编码一种跨膜酪氨酸激酶受体，该受体被认为在造血、精子生成和黑色素生成中发挥重要作用。我们之前的研究表明，c-kit信使RNA在小细胞肺癌中优先表达，其配体干细胞因子在广泛的人类癌症中表达。利用合成多肽的抗c-kit抗血清，用ABC法对c-kit蛋白在人各种实体瘤及相应的胎儿和成人正常组织中的定位进行了研究。结果表明，c-kit基因产物可能参与了非常有限的人类实体肿瘤亚群的发病机制，如小细胞肺癌。有趣的是，在正常和肿瘤的肾上腺髓质细胞中都发现了与c-kit免疫相关的核蛋白。
The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor that is thought to play an important role in hematopoiesis, spermatogenesis, and melanogenesis. We previously showed that the c-kit messenger RNA is preferentially expressed in small cell lung cancer and that its ligand, stem cell factor, is expressed in a broad spectrum of human cancers. Using anti-c-kit antisera raised against synthetic peptides, in situ localization of the c-kit protein in various human solid tumors as well as in corresponding fetal and adult normal tissues was studied by the ABC method. The results suggest that the c-kit gene products may be involved in the pathogenesis of a very restricted subset of human solid tumors such as small cell lung cancer. Interestingly, nuclear protein immunologically related to c-kit was found in both normal and neoplastic medullary cells of the adrenal gland.
单克隆抗体 YB5.B8 可识别人 c-kit 蛋白产物。
影响因子：
20.3
作者：
Lerner,NB;Nocka,KH;Cole,SR;Qiu,FH;Strife,A;Ashman,LK;Besmer,P
通讯作者：
Besmer,P
影响因子：
2.9
作者：
Sumbele S;Fotelli MN;Nikolopoulos D;Tooulakou G;Liakoura V;Liakopoulos G;Bresta P;Dotsika E;Adams MA;Karabourniotis G
通讯作者：
Karabourniotis G