Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay
Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay
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DOI：
10.1037/0735-7044.117.5.1044
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发表时间：
2003-10-01
影响因子：
1.9
通讯作者：
Kesner, RP
中科院分区：
文献类型：
--
作者：
Lee, I;Kesner, RP
为了确定海马各亚区在空间工作记忆中的作用，本研究结合选择性神经毒性损伤海马各亚区与一个简单的延迟nonmatching-to-place任务在大鼠的径向迷宫。海马齿状回或CA 3亚区（而不是CA 1亚区）的损伤诱导了任务获得的缺陷，并伴有短期延迟（即，10 s）和在新环境中任务的表现受损。所有次区域病变在执行任务时产生持续性损伤，并伴有中期延迟（即，5 min）。结果表明，背侧海马各亚区在空间工作记忆加工中存在动态的相互作用，延迟）的任务被认为是一个重要的控制因素。
In order to determine the role of subregions of the hippocampus in spatial working memory, this study combined selective neurotoxic lesions of the hippocampal subregions with a simple delayed nonmatching-to-place task on a radial maze in rats. Lesions of the dentate gyros or the CA3, but not the CA1, subregion of the hippocampus induced a deficit in the acquisition of the task with short-term delays (i.e., 10 s) and impaired performance of the task in a novel environment. All subregional lesions produced sustained impairment in performing the task with intermediate-term delays (i.e., 5 min) when rats were tested in a familiar environment. The results suggest a dynamic interaction among the dorsal hippocampal subregions in processing spatial working memory, with the time window (i.e., delay) of a task recognized as an essential controlling factor.