The special issue on cancer and evolution: Lessons learned.
The special issue on cancer and evolution: Lessons learned.
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关于癌症和进化的特刊：经验教训。
DOI：
10.1111/eva.13040
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发表时间：
2020
影响因子：
4.1
通讯作者：
DeGregori,James
中科院分区：
文献类型：
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作者：
DeGregori,James
这一期关于癌症演变的进化应用的特刊提供了来自该领域领导者的大量不同观点和结果。总之，这些论文强调了广泛视角的重要性，以了解为什么我们和其他动物会患上癌症，它是如何在个体中演变的，以及我们可以做些什么。我们不能再采取简化主义的方法，只考虑癌细胞及其基因。相反，我们需要了解数百万年的进化是如何引导形成癌症风险的策略的，为什么癌症风险在不同动物之间存在差异，癌症风险如何在人群中变化并受到生态的影响（并影响这种生态），当然还有癌症如何在我们体内进化以及进化的策略来应对它们的影响。我在这里的目标将是“把它全部带回家”，提供一个复习的经验教训，增加了kibitzing。
This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in order to understand why we and other animals get cancer, how it evolves within an individual, and what we can do about it. We can no longer take reductionist approaches that consider only the cancer cells and their genes. Instead, we need to understand how millions of years of evolution have guided strategies that shape cancer risk, why cancer risk varies across different animals, how cancer risk can vary in a population and be influenced by ecology (and influence this ecology), and of course how cancers evolve within us and the evolutionarily informed strategies to counter their impact. My goal here will be to “bring it all home,” providing a refresher of lessons learned with added kibitzing.