Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol.

Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol.
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DOI:
10.1038/s41598-020-78885-z
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发表时间:
2020-12-14
期刊:
影响因子:
4.6
通讯作者:
Constable RT
Constable RT
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Horien C;Fontenelle S 4th;Joseph K;Powell N;Nutor C;Fortes D;Butler M;Powell K;Macris D;Lee K;Greene AS;McPartland JC;Volkmar FR;Scheinost D;Chawarska K;Constable RT

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对儿童进行功能磁共振成像 (fMRI) 扫描可能是一项艰巨的任务,因为参与者在扫描时往往会移动。头部运动是功能磁共振成像连接性分析中的一个重要混淆因素。限制运动的一种方法是使用较短的 MRI 协议,但这会降低结果的可靠性。因此,需要实现在不牺牲数据量的情况下获得高质量、低运动数据的方法。在这里,我们展示了通过在扫描前使用模拟扫描协议,结合其他扫描步骤(加权毯和激励系统),可以在接受 60 分钟 MRI 会话的儿科参与者(年龄范围:7-17 岁)中获得低运动 fMRI 数据。我们还观察到,在 MRI 协议期间,单独的复制组参与者(包括一些患有自闭症谱系障碍的参与者)的运动量较低。总的来说,结果表明,在难以扫描的人群中进行长时间扫描方案是可能的,并且仍然可以获得高质量的数据,从而有可能获得更可靠的功能磁共振成像结果。
Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocols, though this reduces the reliability of results. Hence, there is a need to implement methods to achieve high-quality, low-motion data while not sacrificing data quantity. Here we show that by using a mock scan protocol prior to a scan, in conjunction with other in-scan steps (weighted blanket and incentive system), it is possible to achieve low-motion fMRI data in pediatric participants (age range: 7–17 years old) undergoing a 60 min MRI session. We also observe that motion is low during the MRI protocol in a separate replication group of participants, including some with autism spectrum disorder. Collectively, the results indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing more reliable fMRI findings.
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