A novel urinary long non‐coding RNA transcript improves diagnostic accuracy in patients undergoing prostate biopsy
A novel urinary long non‐coding RNA transcript improves diagnostic accuracy in patients undergoing prostate biopsy
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DOI：
10.1002/pros.22949
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发表时间：
2015-05
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通讯作者：
Wei Zhang;S. Ren;Xiaolei Shi;Yawei Liu;Yasheng Zhu;Tai-le Jing;Fubo Wang;R. Chen;Chuan-liang Xu;Hui-qing Wang;Hai-feng Wang;Yan Wang;Bing Liu;Yao-ming Li;Zi-yu Fang;F. Guo;Xin Lu;D. Shen;Xu Gao;J. Hou;Yinghao Sun
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作者：
Wei Zhang;S. Ren;Xiaolei Shi;Yawei Liu;Yasheng Zhu;Tai-le Jing;Fubo Wang;R. Chen;Chuan-liang Xu;Hui-qing Wang;Hai-feng Wang;Yan Wang;Bing Liu;Yao-ming Li;Zi-yu Fang;F. Guo;Xin Lu;D. Shen;Xu Gao;J. Hou;Yinghao Sun
长非编码RNA(LncRNA)PCA3已成为检测前列腺癌(Pca)的尿液生物标志物。我们先前的研究表明，与匹配的良性组织相比，新的LncRNA FR0348383在超过70%的PCa组织中表达上调。本研究的目的是评价尿FR0348383对因PSA升高(PSA和GT；4.0 ng/ml)和/或直肠指检异常(DRE)而接受前列腺活检的男性的诊断价值。
Long non‐coding RNA (LncRNA) PCA3 has been a well‐established urine biomarker for the detection of prostate cancer (PCa). Our previous study showed a novel LncRNA FR0348383 is up‐regulated in over 70% of PCa compared with matched benign tissues. The aim of this study was to evaluate the diagnostic value of urinary FR0348383 for men undergoing prostate biopsy due to elevated PSA (PSA > 4.0 ng/ml) and/or abnormal digital rectal examination (DRE).