Indirect determination of paracetamol in pharmaceutical formulations by inhibition of the system luminol-H2O2-Fe(CN)3-(6) chemiluminescence.
Indirect determination of paracetamol in pharmaceutical formulations by inhibition of the system luminol-H2O2-Fe(CN)3-(6) chemiluminescence.
复制标题
通过抑制鲁米诺-H2O2-Fe(CN)3-(6) 化学发光系统来间接测定药物制剂中的扑热息痛。
DOI：
10.1016/s0731-7085(99)00124-7
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发表时间：
1999
影响因子：
3.4
通讯作者：
J. M. Calatayud
中科院分区：
文献类型：
--
作者：
A. Alapont;L. Zamora;J. M. Calatayud
本文首次提出了Luminol-H_2 O_2-Fe（CN）_（63-）体系用于对乙酰氨基酚的间接测定。该方法是基于对乙酰氨基酚的氧化由六氰基铁（III）和随后的鲁米诺和过氧化氢之间的反应的抑制作用。该方法得到了对乙酰氨基酚在2.5-12.5 μg ml− 1范围内的线性校准图，样品通量为87个样品h−1。研究了杂质的影响，并将该方法应用于三种不同剂型中的药物含量测定。
After a large drug scanning, the system Luminol–H2O2–Fe(CN)63−is proposed for first time for the indirect determination of paracetamol. The method is based on the oxidation of paracetamol by hexacyanoferrate (III) and the subsequent inhibitory effect on the reaction between luminol and hydrogen peroxide. The procedure resulted in a linear calibration graph over the range 2.5–12.5 μg ml−1of paracetamol with a sample throughput of 87 samples h−1. The influence of foreign compounds was studied and, the method was applied to determination of the drug in three different pharmaceutical formulations.