Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients.
Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients.
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锌指蛋白ZnF165是一种新型的癌症剂抗原，能够在肝细胞癌患者中引起抗体反应。
DOI：
10.1038/sj.bjc.6602138
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发表时间：
2004-10-18
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
ZNF 165是从人睾丸组织中发现的一个锌指蛋白基因。对Unigene和SAGE数据库中公开表达的序列标签来源的分析显示，ZNF 165 mRNA在不同组织的肿瘤中表达。RT-PCR、real-time PCR和北方印迹分析证实ZNF 165 mRNA在肝细胞癌、胃癌、结肠癌和非小细胞肺癌中均有表达。肿瘤中表达的ZNF 165的核苷酸序列与睾丸中表达的相同。用重组ZNF 165蛋白进行免疫印迹检测肝癌患者对ZNF 165蛋白的体液应答。抗ZNF 165蛋白的抗体在大约5%（4/82）的HCC患者血清中检测到。这些结果表明，ZNF 165，ZNF家族的成员，是一种新的CT抗原能够引发体液免疫反应，并参与肿瘤生物学。
ZNF165 is a zinc-finger protein gene that was identified from human adult testis. Analysis of the origins of publicly available expressed sequence tags as presented in Unigene and SAGE databases revealed that ZNF165 mRNA was expressed in tumours of different tissues. RT–PCR, real-time PCR and Northern blotting analysis confirmed that ZNF165 mRNA was expressed in the hepatocellular carcinoma, gastric cancer, colon cancer and non-small-cell lung carcinoma. The nucleotide sequence of ZNF165 expressed in tumours is identical to that expressed in the testis. Humoral responses of hepatocellular carcinoma (HCC) patients against ZNF165 protein were determined by Western blotting using the recombinant ZNF165 protein. Antibodies against ZNF165 protein were detected in approximately 5% (four of 82) of the sera from HCC patients. These results suggest that ZNF165, a member of the ZNF family, is a novel CT antigen capable of eliciting humoral immune response and be involved in tumour biology.
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影响因子：
56.9
作者：
BISHOP, JM
通讯作者：
BISHOP, JM
影响因子：
4.8
作者：
Dunaeva, M;Michelson, P;Toftgard, R
通讯作者：
Toftgard, R
影响因子：
3.4
作者：
Jäger, D;Jäger, E;Knuth, A
通讯作者：
Knuth, A
影响因子：
4.7
作者：
Schuler, GD
通讯作者：
Schuler, GD
影响因子：
3.7
作者：
Zwerner, JP;Guimbellot, J;May, WA
通讯作者：
May, WA