Sensorimotor Network Rewiring in Mild Cognitive Impairment and Alzheimer's Disease
Sensorimotor Network Rewiring in Mild Cognitive Impairment and Alzheimer's Disease
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DOI：
10.1002/hbm.20883
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发表时间：
2010-04-01
影响因子：
4.8
通讯作者：
Filippi, Massimo
中科院分区：
文献类型：
--
作者：
Agosta, Federica;Rocca, Maria Assunta;Filippi, Massimo
这项研究旨在阐明：(A)在遗忘性轻度认知损害(AMCI)和阿尔茨海默病(AD)中，与运动功能相关的脑区是否显示出功能磁共振成像(FMRI)信号的变化，(B)这种变化在疾病过程中是线性的，以及(C)aMCI和AD的fMRI变化是由海马萎缩驱动的，还是相反，反映了通常与脑组织损伤有关的非特异性神经元网络重新布线。对10例AD患者、15例aMCI患者和11例健康对照进行了右手占优势的简单运动任务时的功能磁共振成像和结构磁共振成像(即双回波、3D T1加权和扩散张量[DT]序列)。在简单运动任务中，AMCI患者左侧额下回(L)的募集较对照组减少，而L中央后回和L尾状核头部的募集较AD患者增加，扣带回的激活较AD患者减少。AMCI患者初级感觉运动皮质(SMC)与对照组之间以及AD组L尾状核头部SMC与扣带核之间的有效连接均发生改变。改变的fMRI激活和连接与aMCI的海马区萎缩和AD的整体GM微结构损害相关。运动相关功能皮层的改变反映了aMCI和AD认知网络的fMRI变化，提示脑内发生了广泛的重新布线，伴随着结构损伤的增加，而不是认知网络的特定反应。《哼唱大脑地图》31：515-525,2010。(C)2009年Wiley-Liss，Inc.
This study aimed at elucidating whether (a) brain areas associated with motor function show a change in functional magnetic resonance imaging (fMRI) signal in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD), (b) such change is linear over the course of the disease, and (c) fMRI changes in aMCI and AD are driven by hippocampal atrophy, or, conversely, reflect a nonspecific neuronal network rewiring generically associated to brain tissue damage. FMRI during the performance of a simple motor task with the dominant right-hand, and structural MRI (i.e., dual-echo, 3D T1-weighted, and diffusion tensor [DT] MRI sequences) were acquired from 10 AD patients, 15 aMCI patients, and 11 healthy controls. During the simple-motor task, aMCI patients had decreased recruitment of the left (L) inferior frontal gyrus compared to controls, while they showed increased recruitment of L postcentral gyrus and head of L caudate nucleus, and decreased activation of the cingulum compared with AD patients. Effective connectivity was altered between primary sensorimotor cortices (SMC) in aMCI patients vs. controls, and between L SMC, head of L caudate nucleus, and cingulum in AD vs. aMCI patients. Altered fMRI activations and connections were correlated with the hippocampal atrophy in aMCI and with the overall GM microstructural damage in AD. Motor-associated functional cortical changes in aMCI and AD mirror fMRI changes of the cognitive network, suggesting the occurrence of a widespread brain rewiring with increasing structural damage rather than a specific response of cognitive network. Hum Brain Mapp 31:515-525, 2010. (C) 2009 Wiley-Liss, Inc.