Prognostic Indicators of Wound Healing in Atypical Wounds: A Case Series
Prognostic Indicators of Wound Healing in Atypical Wounds: A Case Series
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DOI：
10.1177/1534734620970292
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发表时间：
2020-11-11
影响因子：
1.7
通讯作者：
Dini, Valentina
中科院分区：
文献类型：
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作者：
Janowska, Agata;Romanelli, Marco;Dini, Valentina
愈合率是预测愈合的最准确方法;然而，在非典型溃疡中没有数据。我们回顾性分析了159例非典型溃疡患者的临床特征、相关合并症和治疗方法。在59例患者的亚组中，我们分析了面积、周长和愈合率（mm/d）作为伤口愈合的预后指标。非典型溃疡在平均年龄为76岁的女性（n = 98）中更常见。经活检证实，病因如下：炎性疾病（38%）、肿瘤性溃疡（29%）、血管炎（21%）、药物性溃疡（7%）和感染性溃疡（4%）。根据不同的病因进行全身治疗。创面床准备原则指导局部治疗。在观察间隔期间，面积平均减少36%，而周长平均减少41%。总体而言，51个溃疡显示伤口尺寸减小，8个溃疡显示伤口尺寸增大。肿瘤性溃疡愈合速度最快，平均愈合速度为0.24 mm/d。炎症组愈合最慢，平均愈合率为0.032mm/d。初始面积和周长影响伤口愈合;然而，溃疡病因和合并症显著改变愈合率。
Healing rate is the most accurate method to predict healing; however, there are no data in atypical ulcers. We retrospectively analyzed clinical features, associated comorbidities, and therapies of 159 patients with atypical ulcers. In a subgroup of 59 patients, we analyzed the areas, perimeters, and the healing rate (mm/d) as prognostic indicators of wound healing. Atypical ulcers were more frequent among women (n = 98) with an average age of 76 years. Confirmed by biopsy, the etiologies were as follows: inflammatory diseases (38%), neoplastic ulcers (29%), vasculitis (21%), drug-induced ulcers (7%), and infectious ulcers (4%). Systemic therapies were applied based on the different etiologies. Wound bed preparation principles guided the local treatment. The average reduction of the area during the observation interval was 36%, while the average reduction in the perimeter was 41%. Overall, 51 ulcers showed a reduction in wound size and 8 ulcers showed an increase. Neoplastic ulcers were the group with the fastest healing rate, with an average speed of 0.24 mm/d. The slowest healing occurred in the inflammatory group with an average healing rate of 0.032 mm/d. The initial area and perimeters influenced wound healing; however, ulcer etiology and comorbidities significantly altered the healing rate.