Expression of P27kip 1 and Ki-67 in Pituitary Adenomas: An Investigation of Marker of Adenoma Invasiveness
Expression of P27kip 1 and Ki-67 in Pituitary Adenomas: An Investigation of Marker of Adenoma Invasiveness
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P27kip 1和Ki-67在垂体腺瘤中的表达：腺瘤侵袭性标志物的研究
DOI：
10.1007/s007010050285
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发表时间：
1999
影响因子：
2.4
通讯作者：
T. Nose
中科院分区：
文献类型：
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作者：
D. Zhao;Y. Tomono;T. Nose
与其他内分泌肿瘤相似，组织学对垂体腺瘤的侵袭性预测能力较差。因此，对123例垂体腺瘤标本（包括57例临床证实的侵袭性病例）进行了免疫组织化学研究，蛋白质p27 Kip 1（p27）和Ki-67分别阻断细胞周期进程和反映细胞增殖活性。只有Ki-67与侵袭性显著相关;只有p27在功能性和非功能性腺瘤之间存在显著差异，前者的细胞标记频率更高。Ki-67与p27之间无相关性。因此，MIB-1检测Ki-67是一个重要的标志物，与腺瘤的侵袭潜力，从而可能有助于计划垂体腺瘤患者的术后管理。
Summary Mirroring the ambiguities noted with other endocrine tumours, histology is a poor predictor of the invasiveness of pituitary adenomas. Accordingly, the proteins p27Kip 1 (p27) and Ki-67, which respectively block cell-cycle progression and reflect proliferative activity of cells, were studied immunohistochemically in 123 specimens of pituitary adenomas including 57 clinically verified invasive cases. Only Ki-67 had a significant association with invasiveness; only p27 differed significantly between functioning and nonfunctioning adenomas, with a higher frequency of cell labelling in the former. No relationship between Ki-67 and p27 was obtained. Ki-67 detected by MIB-1 is thus an important marker related to the invasive potential of adenomas, and thereby may be helpful in planning postoperative management of patients with pituitary adenomas.
DOI：
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发表时间：
1997-02
期刊：
The American journal of pathology
影响因子：
--
作者：
Ricardo V. Lloyd;Long Jin;X. Qian;E. Kulig
通讯作者：
Ricardo V. Lloyd;Long Jin;X. Qian;E. Kulig
垂体细胞中转化生长因子-β 和 p27 的表达。
DOI：
10.1210/endo.137.7.8770931
发表时间：
1996
期刊：
Endocrinology.
影响因子：
--
作者：
Qian,X;Jin,L;Grande,JP;Lloyd,RV
通讯作者：
Lloyd,RV
影响因子：
15.9
作者：
Chen, J;Willingham, T;Nisen, PD
通讯作者：
Nisen, PD