Affective style and in vivo immune response:: Neurobehavioral mechanisms
Affective style and in vivo immune response:: Neurobehavioral mechanisms
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DOI：
10.1073/pnas.1534743100
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发表时间：
2003-09-16
影响因子：
11.1
通讯作者：
Davidson, RJ
中科院分区：
文献类型：
--
作者：
Rosenkranz, MA;Jackson, DC;Davidson, RJ
有相当多的证据支持心理状态和免疫功能之间的联系。然而，这些状态在大脑中实例化并影响免疫系统的机制却知之甚少。本研究探讨了情感风格、心理健康和免疫功能的生理指标之间的关系。通过自传体写作任务，研究者获得了积极和消极的情感。采用脑电图和情绪调节眨眼惊吓测量特质和状态负性情绪。参与者接种流感疫苗，并测定疫苗接种后的抗体滴度，以提供免疫功能的体内测量。较高水平的右前额叶脑电图激活和更大幅度的惊吓反射可靠地预测较差的免疫反应。这些数据支持这样的假设，即具有更消极情感风格的个体的免疫反应较弱，因此可能比具有更积极情感风格的个体更容易患病。
Considerable evidence exists to support an association between psychological states and immune function. However, the mechanisms by which such states are instantiated in the brain and influence the immune system are poorly understood. The present study investigated relations among physiological measures of affective style, psychological well being, and immune function. Negative and positive affect were elicited by using an autobiographical writing task. Electroencephalography and affect-modulated eye-blink startle were used to measure trait and state negative affect. Participants were vaccinated for influenza, and antibody titers after the vaccine were assayed to provide an in vivo measure of immune function. Higher levels of right-prefrontal electroencephalographic activation and greater magnitude of the startle reflex reliably predicted poorer immune response. These data support the hypothesis that individuals characterized by a more negative affective style mount a weaker immune response and therefore may be at greater risk for illness than those with a more positive affective style.