Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.
Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.
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DOI：
10.1097/nen.0b013e3181c1da10
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发表时间：
2009-12
影响因子：
3.2
通讯作者：
LeBlanc AC
中科院分区：
文献类型：
--
作者：
Albrecht S;Bogdanovic N;Ghetti B;Winblad B;LeBlanc AC
我们之前在轻度、中度、重度和非常严重的阿尔茨海默病(AD)病例中证明了Caspase-6在海马区和皮质中的激活。为了确定Caspase-6在家族性AD中是否也被激活，我们对家族性AD患者的颞叶皮质和海马区组织切片中活化的Caspase-6和被Caspase-6切割的Tau进行了免疫组织化学分析。其中5例携带淀粉样前体蛋白K670N，M671L瑞典突变，1例携带淀粉样前体蛋白E693G北极突变，2例分别携带早老素I M146V、F105L、A431E、V261F、Y115C突变，1例早老素II N141I突变。所有病例均呈Caspase-6免疫反应阳性。Caspase-6免疫反应见于神经炎性斑块或棉球斑块、神经纤维束和神经纤维束。这些结果表明，Caspase-6在家族性AD中被激活，正如以前在散发性AD中观察到的那样。由于散发性和家族性AD具有相似的病理特征，这些结果支持Caspase-6在家族性和散发性AD的病理生理学中的基础作用。
We previously demonstrated the activation of Caspase-6 in the hippocampus and cortex in cases of mild, moderate, severe and very severe Alzheimer disease (AD). To determine whether Caspase-6 is also activated in familial AD, we performed an immunohistochemical analysis of active Caspase-6 and Tau cleaved by Caspase-6 in temporal cortex and hippocampal tissue sections from cases of familial AD. The cases included 5 carrying the amyloid precursor protein K670N, M671L Swedish mutation, 1 carrying the amyloid precursor protein E693G Arctic mutation, 2 each carrying the Presenilin I M146V, F105L, A431E, V261F, Y115C mutations, and 1 with the Presenilin II N141I mutation. Active Caspase-6 immunoreactivity was found in all cases. Caspase-6 immunoreactivity was observed in neuritic plaques or cotton wool plaques in some cases, neuropil threads and neurofibrillary tangles. These results indicate that Caspase-6 is activated in familial forms of AD, as previously observed in sporadic forms. Since sporadic and familial AD cases have similar pathological features, these results support a fundamental role of Caspase-6 in the pathophysiology of both familial and sporadic AD.