Effect of alkylphenols on adult male medaka: plasma vitellogenin goes up to the level of estrous female
Effect of alkylphenols on adult male medaka: plasma vitellogenin goes up to the level of estrous female
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DOI：
10.1016/j.etap.2003.08.005
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发表时间：
2003-12-01
影响因子：
4.3
通讯作者：
Tamiya, E
中科院分区：
文献类型：
--
作者：
Chikae, M;Ikeda, R;Tamiya, E
研究了口服双酚A（BPA）、对叔辛基酚（OP）、对壬基酚（NP）和对正壬基酚（n-NP）4种烷基酚以及17 α-乙炔基酚（EE 2）对雄性青鳉鱼卵黄蛋白原的影响。雄性青鳉被喂食含有不同浓度的这些化学物质的饮食7天，之后测量它们的血浆卵黄原蛋白水平。卵黄蛋白原含量高达10（7）ng/ml，接近于正常发情期雌性青鳉的水平。中位有效浓度（EC 50）值产生的BPA，OP，NP和EE 2的饮食分别计算为1600，2600，940和0.37微克/克饮食。(C)2003 Elsevier B. V.保留所有权利。
The effect that oral administration of four alkylphenols, (1) bisphenol A (BPA), (2) p-t-octylphenol (OP), (3) p-nonylphenol (NP) and (4) p-n -nonylphenol (n- NP), as well as 17alpha-ethynylestradiol (EE2) had on male medaka fish vitellogenin was investigated. The male medaka was fed diets containing different concentrations of these chemicals for 7 days, after which their plasma vitellogenin levels were measured. Vitellogenin levels up to approximate to 10(7) ng/ml were found. This value is close to that of the normal estrous female medaka. The median effective concentration (EC50) values resulting from BPA, OP, NP and EE2 in the diet were calculated as 1600, 2600 940 and 0.37 mug/g diet, respectively. (C) 2003 Elsevier B.V. All rights reserved.