EVIDENCE THAT TOBACCO SMOKING INCREASES THE DENSITY OF (-)-[H-3]NICOTINE BINDING-SITES IN HUMAN-BRAIN
EVIDENCE THAT TOBACCO SMOKING INCREASES THE DENSITY OF (-)-[H-3]NICOTINE BINDING-SITES IN HUMAN-BRAIN
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DOI：
10.1111/j.1471-4159.1988.tb10600.x
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发表时间：
1988-04-01
影响因子：
4.7
通讯作者：
ANDERSON, JM
中科院分区：
文献类型：
--
作者：
BENWELL, MEM;BALFOUR, DJK;ANDERSON, JM
在对人脑中烟碱受体的死后研究中，发现吸烟与（-）-[3 H]烟碱与直回制备的膜的结合增加有关（Brodmann 11区）（p < 0.001），海马新皮质（布罗德曼27区），小脑皮质（p < 0.01）、海马结构（Ammon's horn + subiculum）和中脑的中缝核（p < 0.05），但延髓没有。结合数据分析表明，结合增加反映了受体密度的增加，而不是其对（-）-尼古丁亲和力的变化。吸烟的影响不受性别或年龄的主题显着。它的结论是，吸烟引起的高亲和力尼古丁结合的增加，类似于以前观察到的动物长期与尼古丁治疗，吸烟对这些网站的影响可能是由烟草烟雾中存在的尼古丁。
In a postmortem study of nicotinic receptors in human brain, cigarette smoking was found to be associated with increased (-)-[3H]nicotine binding to membranes prepared from gyrus rectus (Brodmann area 11) (p < 0.001), hippocampal neocortex (Brodmann area 27), cerebellar cortex (p < 0.01), hippocampal formation (Ammon''s horn + subiculum), and the median raphe nuclei of the midbrain (p < 0.05) but not the medulla oblongata. Analysis of the binding data suggested that the increased binding reflected an increase in the density of the receptors rather than a change in their affinity for (-)-nicotine. The effects of smoking were not influenced significantly by either the sex or age of the subject. It is concluded that smoking evokes an increase in high-affinity nicotine binding similar to that observed previously in animals treated chronically with nicotine and that the effect of smoking on these sites is probably caused by the nicotine present in the tobacco smoke.