The relationship between body mass index across the life course and knee pain in adulthood: results from the 1958 birth cohort study
The relationship between body mass index across the life course and knee pain in adulthood: results from the 1958 birth cohort study
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DOI：
10.1093/rheumatology/ker276
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发表时间：
2011-12-01
期刊：
影响因子：
5.5
通讯作者：
Jones, Gareth T.
中科院分区：
文献类型：
--
作者：
Macfarlane, Gary J.;de Silva, Vijitha;Jones, Gareth T.
方法.对1958年第一周出生的英国人进行的出生队列研究。参与者在整个童年和成年期进行了随访，最近一次是在45岁时，当时收集了有关膝关节疼痛的信息。在整个儿童期和成年期的随访期间收集BMI信息。共有8579人参与，超重和肥胖的患病率从7岁时的0.2%增加到45岁时的65.5%。共有1636名患者在45岁时报告膝关节疼痛，患病率为19.1%（95% CI 18.2，19.9%）。BMI与膝关节疼痛相关：23、33或45岁时BMI> 30 kg/m2的人在45岁时患膝关节疼痛的风险大约增加一倍。早在11岁时，45岁时的膝关节疼痛与高BMI就存在显着相关性，但在16岁时这种相关性更强[相对风险（RR）（BMI 20-25）（vs）（< 20）= 1.2（95%CI 1.1，1.3）; RR 25 -30 = 1.3（95%CI 1.1，1.6）; RR > 30 = 1.6（95%CI 1.05，2.4）]。这项研究证明了儿童和早期成人肥胖的长期影响以及早期干预计划的重要性，以减少体重并保持体重减轻。
Methods. A birth cohort study of persons born during first week of 1958 in Great Britain. Participants were followed up throughout childhood and adulthood, most recently at 45 years, when information was collected on knee pain. Information on BMI was collected at follow-up intervals throughout childhood and adulthood.Results. A total of 8579 individuals participated and the prevalence of being overweight and obesity increased throughout life from 0.2% at the age of 7 years to 65.5% at the age of 45 years. A total of 1636 individuals reported knee pain at the age of 45 years, giving a prevalence of 19.1% (95% CI 18.2, 19.9%). BMI was associated with knee pain: persons with a BMI of > 30 kg/m(2) at 23, 33 or 45 years experienced approximately a doubling in the risk of knee pain at 45 years. There was a significant association with knee pain at the age of 45 years with high BMI from as early as age 11 years, but the association was stronger at the age of 16 years [relative risk (RR)(BMI 20-25) (vs) (< 20) = 1.2 (95% CI 1.1, 1.3); RR25-30 = 1.3 (95% CI 1.1, 1.6); RR > 30 = 1.6 (95% CI 1.05, 2.4)].Conclusion. This study has demonstrated the long-term effects of childhood and early adult obesity and the importance of early intervention programmes to try to reduce weight and maintain weight loss.