PATTERNS OF EXPLORATION IN RATS DISTINGUISH LISURIDE FROM LYSERGIC-ACID DIETHYLAMIDE
PATTERNS OF EXPLORATION IN RATS DISTINGUISH LISURIDE FROM LYSERGIC-ACID DIETHYLAMIDE
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DOI：
10.1016/0091-3057(85)90022-x
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
GEYER, MA
中科院分区：
文献类型：
--
作者：
ADAMS, LM;GEYER, MA
为了进一步验证先前提出的LSD对人类影响的动物模型，剂量为5、15、30和60 .mu。使用行为模式监测仪（BPM）研究g/kg lisuride （LSD的非致幻同系物）。BPM提供了交叉、后移和孔洞的定量测量和运动空间模式的定性测量。连接到房屋的孔板室提供了两种测试情况。大鼠分为两组（自由探索）和两组（强制探索）。在两种情况下，利尿苷水平运动表现出双相剂量-反应曲线（低剂量抑制和高剂量增强），而饲养在所有剂量下均显著降低。Lisuride还产生了运动模式持续质量的剂量依赖性增加。将这些结果与我们之前对麦角酸二乙醛（LSD）的研究结果进行比较表明，除了饲养外，lisuride无法模仿LSD对探索活动的特征影响。相反，lisuride表现出许多与多巴胺受体阿帕吗啡相似的地方。
In order to further validate a previously proposed animal model of the effects of LSD in humans, doses of 5, 15, 30 and 60 .mu.g/kg lisuride (a non-hallucinogenic congener of LSD) were studied using a behavioral pattern monitor (BPM). The BPM provided both quantitative measures of crossovers, rearings, and holepokes and qualitative measures of spatial patterns of locomotion. A holeboard chamber connected to a homecage provided two test situations. Rats were tested either with (free exploration) or without access to the homecage (forced exploration). In both situations, lisuride exhibited a biphasic dose-response curve for horizontal locomotion (low dose suppression and high dose enhancement), while rearing was significantly reduced at all doses. Lisuride also produced a dose-dependent increase in the perseverative quality of locomotor patterns. A comparison of these results with our previous studies with lysergic acid diethalmide (LSD) indicate that, with the exception of rearings, lisuride fails to mimic LSD''s characteristic effects on exploratory activity. Rather, lisuride exhibited many similarities to the dopamine angonist apomorphine.