From bench to bedside: the growing use of translational research in cancer medicine.
From bench to bedside: the growing use of translational research in cancer medicine.
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DOI：
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发表时间：
2010
影响因子：
2.2
通讯作者：
Erin M. Goldblatt;Wen-Hwa Lee
中科院分区：
文献类型：
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作者：
Erin M. Goldblatt;Wen-Hwa Lee
癌症是造成全世界八分之一死亡的原因，每年诊断出超过一千二百万新病例。尽管进行了积极的治疗，但仍有很大比例的患者在发展为癌症后死亡，这表明需要新的癌症治疗方法。对新型诊断和治疗药物开发的推动使转化癌症研究蓬勃发展。基因组和蛋白质组技术已经产生了大量的信息，这些信息对于扩大我们对癌症生物学的理解至关重要。关于正常和恶性细胞生物学之间差异的新研究为开发针对特定生物分子的药物铺平了道路，可能会增加抗肿瘤疗效，同时最大限度地减少传统疗法对患者的毒性。目前的靶点包括细胞周期、血管生成、凋亡、DNA修复和生长因子及其受体的调节剂。研究人员、临床医生和制药公司之间的合作对于开展临床试验将实验室发现转化为临床适用的疗法至关重要。在这篇综述中，我们讨论了目前的治疗方法，并介绍了一个广泛的主题正在调查，努力突出临床相关的治疗策略的发展转化研究的重要性。
Cancer is responsible for one in eight deaths worldwide, with more than twelve million new cases diagnosed yearly. A large percentage of patients die after developing cancer despite aggressive treatment, indicating a need for new approaches to cancer therapy. The push for development of novel diagnostic and therapeutic agents has allowed translational cancer research to flourish. Genomic and proteomic technologies have generated an enormous amount of information critical to expanding our understanding of cancer biology. New research on the differences between normal and malignant cell biology has paved the way for the development of drugs targeted to specific biological molecules, potentially increasing antitumor efficacy while minimizing the toxicity to the patient that is seen with conventional therapeutics. Current targets in include regulators of cell cycle, angiogenesis, apoptosis, DNA repair, and growth factors and their receptors. Collaboration among researchers, clinicians, and pharmaceutical companies is vital to conducting clinical trials to translate laboratory findings into clinically applicable therapeutics. In this review, we discuss current therapeutic approaches and present an introduction to a wide range of topics undergoing investigation in an effort to highlight the importance of translational research in the development of clinically relevant therapeutic strategies.