Yearning predicts subgenual anterior cingulate activity in bereaved individuals.
Yearning predicts subgenual anterior cingulate activity in bereaved individuals.
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DOI：
10.1016/j.heliyon.2018.e00852
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发表时间：
2018-10
期刊：
影响因子：
4
通讯作者：
O'Connor MF
中科院分区：
文献类型：
--
作者：
McConnell MH;Killgore WDS;O'Connor MF
复杂性悲伤，或称持续性复杂丧亲症，是一种影响大约 10% 丧亲者的病症，其特点是对死者的强烈渴望和向往。人们对导致这种综合征的神经认知机制知之甚少，但之前的研究表明大脑中的奖励通路可能发挥了作用。根据悲伤严重程度，将 25 名老年人分为三组：复杂悲伤 (CG)、非复杂悲伤 (NCG) 和非丧亲已婚对照组 (NB)。使用功能磁共振成像检查神经激活，参与者观看屏幕上的倒计时（预期），然后观看他们（在世或已故）配偶的照片。三组之间对于配偶与陌生人照片对比以及预期期与配偶照片的激活没有显着差异。使用自我报告的渴望得分作为所有失去亲人的参与者的回归量进行事后分析，结果表明，渴望症状越强烈，膝下前扣带皮层（sgACC）的激活程度就越高。鉴于样本量较小，结果应被视为初步结果并需要复制，但可能表明 sgACC 具有更微妙的跨诊断作用。大脑的这个区域之前已被认为与抑郁症有关，并且表明渴望症状可能是一个适当的干预场所，以改善 CG 的结果。
Complicated grief, or persistent complex bereavement disorder, is a condition that affects approximately 10% of bereaved individuals and is marked by intense longing and yearning for the deceased. Little is known about the neurocognitive mechanisms contributing to this syndrome, but previous research suggests that reward pathways in the brain may play a role. Twenty-five older adults were categorized based on grief severity into one of three groups: complicated grief (CG), non-complicated grief (NCG) and non-bereaved married controls (NB). Neural activation was examined using fMRI while participants viewed a countdown on the screen (anticipation) followed by a photo of their (living or deceased) spouse. There was no significantly differential activation between the three groups for the spouse v. stranger photo contrast, nor for anticipation period v. spouse photo. Post-hoc analyses were conducted using self-reported yearning scores as a regressor across all bereaved participants, which revealed that greater symptoms of yearning predicted greater activation in the subgenual anterior cingulate cortex (sgACC). Given the small sample size, the results should be considered preliminary and in need of replication, but may suggest a more nuanced, transdiagnostic role of the sgACC. This region of the brain has been previously linked to depression and suggests that symptoms of yearning may present an opportune place to intervene to improve outcomes in CG.