Heterogeneity in fetal growth velocity
Heterogeneity in fetal growth velocity
复制标题
胎儿生长速度的异质性
DOI：
10.1038/s41598-019-47839-5
复制
发表时间：
2019
影响因子：
4.6
通讯作者：
Miyasaka Naoyuki
中科院分区：
文献类型：
--
作者：
Sato Noriko;Miyasaka Naoyuki
胎儿生长质量与非传染性疾病的易感性有关。胎儿大小通常使用平均生长图进行评估，但胎儿生长速度最近作为胎儿发育的另一个重要方面引起了人们的关注。由于胎儿生长速度可以反映胎儿在母体约束下发育过程中对各种条件的反应，因此可以合理地想象，随着时间的推移，生长速度模式可能存在生理多样性，这从未被探索过。我们进行了一项回顾性队列研究，旨在评估日本人群中单胎妊娠胎儿生长速度的异质性。我们利用产前检查的高频率来收集每个胎儿（N = 801）的大量超声测量值，并计算分析每周生长的个体变化。潜类轨迹分析确定了三种不同的速度模式。生长速度的变化出现在孕晚期，并对应于新生儿大小的差异。这种异质性不能简单地用母体因素和胎儿性别来解释，尽管这些因素对胎儿大小有随时间变化的影响。我们关于胎儿生长速度异质性的研究结果将有助于全面了解胎儿发育质量。
Fetal growth quality is associated with susceptibility to non-communicable diseases. Fetal size has been conventionally assessed using the averaged growth chart, but fetal growth velocity has recently been attracting attention as another important aspect of fetal development. Since fetal growth velocity may reflect fetal response to various conditions during the developmental process within the maternal constraint, it is reasonable to imagine that there might exist a physiological diversity in growth velocity patterns over time, which has never been explored. We conducted a retrospective cohort study designed to evaluate the heterogeneity of fetal growth velocity in singleton pregnancies in the Japanese population. We leveraged the high frequency of prenatal checkup to collect large numbers of ultrasound measurements of every fetus (N = 801) and computationally analyzed individual changes in growth per week. Latent class trajectory analysis identified three distinct velocity patterns. The variation in growth velocity appeared in the third trimester and corresponded to the differences in neonatal size. This heterogeneity was not simply explained by maternal factors and fetal sex, although those factors had time-varying effects on fetal size. Our findings regarding the heterogeneity in fetal growth velocity will aid in the comprehensive understanding of fetal development quality.