Distribution of the molossinus allele of Sry, the testis-determining gene, in wild mice.
Distribution of the molossinus allele of Sry, the testis-determining gene, in wild mice.
复制标题
DOI：
10.1093/oxfordjournals.molbev.a040169
复制
发表时间：
1994-11
影响因子：
10.7
通讯作者：
C. Nagamine;T. Shiroishi;N. Miyashita;K. Tsuchiya;H. Ikeda;N. Takao;X. L. Wu;M. Jin;F. Wang;A. Kryukov
中科院分区：
文献类型：
--
作者：
C. Nagamine;T. Shiroishi;N. Miyashita;K. Tsuchiya;H. Ikeda;N. Takao;X. L. Wu;M. Jin;F. Wang;A. Kryukov
当实验室近交系小鼠C57BL/6(B6)的Y染色体被某些家鼠品系的Y染色体取代时，睾丸测定失败，所有XY胎儿要么发育为两性个体，要么发育为XY雌性个体(XY性别反转)。这表明至少存在Sry的两个等位基因，Sry是Y：M.home ticus和B6上的男性决定基因。B6Y染色体来自日本家鼠M.molossinus，因此携带MolossinesSry等位基因。作为确定MolossinesSry等位基因如何进化的第一步，我们确定了它在野生小鼠中的分布模式。来自欧洲、北非和亚洲58个地理位置的96份肌肉标本的累积数据表明，Molossinus Sry等位基因仅限于日本和邻近的亚洲大陆，并证实日本M.molossinus小鼠部分来自韩国或满洲里的M.m.musculus小种。SRY基因的多态性可以作为研究野生肌肉分枝杆菌种群进化的分子标记，并有助于确定性别决定在物种形成中的作用。
When the Y chromosome of the laboratory inbred mouse strain C57BL/6 (B6) is replaced by the Y of certain strains of Mus musculus domesticus, testis determination fails and all XY fetuses develop either as hermaphrodites or XY females (XY sex reversal). This suggests the presence of at least two alleles of Sry, the male-determining gene on the Y:M. m. domesticus and B6. The B6 Y chromosome is derived from the Japanese house mouse, M. m. molossinus and therefore carries a molossinus Sry allele. As a first step to determine how the molossinus Sry allele evolved, its distribution pattern was determined in wild mice. The cumulative data of 96 M. musculus samples obtained from 58 geographical locations in Europe, North Africa, and Asia show the molossinus Sry allele is restricted to Japan and the neighboring Asian mainland and confirm that Japanese M. m. molossinus mice were derived in part from a race of M. m. musculus from Korea or Manchuria. Sry polymorphisms, as illustrated by the molossinus Sry allele, can serve as molecular markers for studies on the evolution of wild M. musculus populations and can help determine the role sex determination plays in speciation.