Influence of BMI and gender on postprandial hormone responses
Influence of BMI and gender on postprandial hormone responses
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DOI：
10.1038/oby.2007.355
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发表时间：
2007-12-01
期刊：
影响因子：
6.9
通讯作者：
Caffrey, James L.
中科院分区：
文献类型：
--
作者：
Carroll, Joan F.;Kaiser, Kathryn A.;Caffrey, James L.
目的：性别和体重对饮食激素反应的影响尚不清楚。本研究旨在确定一个方便的时间点来评估餐后激素反应的峰值，并验证性别和BMI相互作用会导致餐后与饥饿和饱腹感相关的选定体液标志物分泌差异的假设。研究方法和程序：测定正常体重（20 = 30 kg/m）男性（n = 9）和女性（n = 11）的空腹血糖、胰岛素、瘦素、胃饥饿素、胰高血糖素样肽-1和胰高血糖素。摄入一份标准液体餐，每10分钟重复一次体液测量，持续1小时。数据分析采用重复测量方差分析，以BMI和性别为主要影响因素。结果：肥胖受试者胰岛素反应峰值延迟（p = 0.004），而肥胖男性胃促生长素反应最低点延迟（p = 0.05）。肥胖受试者的餐后血糖水平较高且持续时间更长（p = 0.02），空腹（p = 0.0004）和餐后胰岛素水平较高（p = 0.0001）。胃饥饿素在餐后降低（p = 0.003）；肥胖受试者禁食后的百分比变化倾向于降低（p = 0.07）。男性空腹（p = 0.02）和餐后（p = 0.03）胰高血糖素较高，餐后血浆瘦素略有下降（p = 0.01）。讨论：激素反应高峰发生在进食后20 - 40分钟。在这段时间内进行的测量可能有助于评估餐后反应的强度。餐后反应的高峰/最低点和时间过程受性别和BMI的影响。营养研究需要考虑到这些因素带来的可变性。
Objective: Influences of gender and body weight on the hormonal response to eating are not well understood. This study was conducted to determine a convenient time-point to evaluate peak postprandial hormone responses and to test the hypothesis that gender and BMI interact to produce differences in postprandial secretion of selected humoral markers implicated in hunger and satiety.Research Methods and Procedures: Fasting blood glucose, insulin, leptin, ghrelin, glucagon-like peptide-1, and glucagon were measured in normal-weight (20 = 30 kg/m(2)) men (n = 9) and women (n = 11). A standard liquid meal was consumed, and humoral measurements were repeated every 10 minutes for I hour. Data were analyzed using repeated measures ANOVA with BMI and gender as main effects.Results: Obese subjects had delayed peak insulin responses (p = 0.004), whereas obese men had a delayed nadir ghrelin response (p = 0.05). Obese subjects had higher and more sustained postprandial glucose (p = 0.02), and greater fasting (p = 0.0004) and postprandial insulin (p = 0.0001). Ghrelin decreased after the meal (p = 0.003); the percent change from fasting tended to be reduced in obese subjects (p = 0.07). Men had greater fasting (p = 0.02) and postprandial (p = 0.03) glucagon and a subtle postprandial decline in plasma leptin (p = 0.01).Discussion: Peak hormone responses occurred 20 to 40 minutes after eating. Measurements made during this interval may be useful in evaluating postprandial response magnitude. Peak/nadir responses and time courses of postprandial responses are influenced by gender and BMI. Nutritional studies need to account for variability introduced by these factors.