PHARMACOKINETIC PROPERTIES OF NOSCAPINE
PHARMACOKINETIC PROPERTIES OF NOSCAPINE
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DOI：
10.1007/bf00609627
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发表时间：
1982-01-01
影响因子：
2.9
通讯作者：
JOHANSSON, M
中科院分区：
文献类型：
--
作者：
DAHLSTROM, B;MELLSTRAND, T;JOHANSSON, M
诺斯汀是一种从鸦片中提取的异喹啉生物碱。它被用作止咳药。]5名健康志愿者以随机交叉设计静脉注射诺伐他汀。输注66毫克，口服150毫克速溶片或含有离子交换树脂结合的诺斯汀的片剂。静脉注射后。给药后，诺伐他汀呈双指数分布，消除半衰期为2.6h，血浆总清除量为22ml/min/kg，分布体积为4.7/1/kg。口服的绝对生物利用度为30%，个体间差异为3.6倍。不支持离子交换树脂片剂的长期作用。
[Noscapine is an isoquinoline alkaloid obtained from opium. It is used as a cough suppressant.] Noscapine was administered to 5 healthy volunteers in a randomized crossover design, as an i.v. infusion of 66 mg, and as an oral 150-mg dose of either rapidly dissolving tablets or a tablet containing ion exchange resin-bound noscapine. After i.v. administration, the disposition of noscapine was biexponential, with an elimination half-life of 2.6 h; the total plasma clearance was 22 ml/min per kg and the volume of distribution (Vdarea) was 4.7/1/kg. The absolute oral bioavailability was 30%, with a 3.6-fold interindividual variation. A prolonged action of the ion exchange resin tablet was not supported.