Advances in functional magnetic resonance imaging of the human brainstem
Advances in functional magnetic resonance imaging of the human brainstem
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DOI：
10.1016/j.neuroimage.2013.07.081
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发表时间：
2014-02-01
期刊：
影响因子：
5.7
通讯作者：
Baer, Karl-Juergen
中科院分区：
文献类型：
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作者：
Beissner, Florian;Schumann, Andy;Baer, Karl-Juergen
脑干对我们的日常生存至关重要，然而各种核之间的功能关系，它们的投射目标和传入调节区域仍然缺乏特征。其主要原因在于标准神经成像方法在这一领域的次优性能。特别是，与皮质区域相比，功能磁共振成像信号在脑干区域更难探测到。在这里，我们描述并验证了一种使用标准的功能磁共振成像序列和广泛可用的统计图像处理工具来测量人类脑干核激活的新方法。通过在空间上将独立成分分析限制在解剖学定义的脑干面罩上，我们从分析中排除了那些受生理噪声强烈影响的区域。这使我们第一次确定了人类脑干的内在连接网络，并绘制了纯粹基于功能定义的感兴趣区域的脑干-皮层连接图。(C) 2013年作者。Elsevier Inc.出版。版权所有。
The brainstem is of tremendous importance for our daily survival, and yet the functional relationships between various nuclei, their projection targets, and afferent regulatory areas remain poorly characterized. The main reason for this lies in the sub-optimal performance of standard neuroimaging methods in this area. In particular, fMRI signals are much harder to detect in the brainstem region compared to cortical areas. Here we describe and validate a new approach to measure activation of brainstem nuclei in humans using standard fMRI sequences and widely available tools for statistical image processing. By spatially restricting an independent component analysis to an anatomically defined brainstem mask, we excluded those areas from the analysis that were strongly affected by physiological noise. This allowed us to identify for the first time intrinsic connectivity networks in the human brainstem and to map brainstem-cortical connectivity purely based on functionally defined regions of interest. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.