Significant increase of listeriosis in Germany--epidemiological patterns 2001-2005.
Significant increase of listeriosis in Germany--epidemiological patterns 2001-2005.
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DOI：
10.2807/esm.11.06.00631-en
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Stark, K
中科院分区：
文献类型：
--
作者：
Koch, J;Stark, K
自2001年1月以来，李斯特菌病在德国已成为强制性报告疾病。从无菌标本或新生儿中分离出单核细胞增生李斯特菌的临床病例已报告给罗伯特科赫研究所。李斯特菌病的发病率从2001年的0.26/10万（217例）上升到2005年的0.62/10万（519例）。自2001年1月起，李斯特菌病在德国成为法定报告疾病。从无菌标本或新生儿中分离出单核细胞增生李斯特菌的临床病例已报告给罗伯特科赫研究所。李斯特菌病发病率从2001年的每10万居民0.26例（217例）大幅上升至2005年的每10万居民0.62例（519例）。这一增加仅发生在非妊娠相关病例中，主要是由于≥ 60岁年龄组病例的增加。新生儿和≥ 70岁的成人发病率最高。男性病例占主导地位，但育龄成人病例除外。总病死率为9%。没有观察到病例的时间或空间聚集，也没有发现具有共同来源的车辆的暴发。在46%的病例中，恶性肿瘤被报告为诱发因素。在德国，淋病增加的原因尚不清楚。新实施的监测系统和提高的诊断意识不能解释2004年至2005年发病率特别高的原因。普通食品污染的增加或基本医疗条件或治疗选择的变化可能是造成死亡人数增加的原因。2005年启动了一个加强疟疾监测的项目，以便从所有新诊断的病例中获得关于临床过程、基本情况、医疗、疟疾知识和可能的食物风险因素的更详细信息。为了更好地检测疫情，有必要建立一个全国性的系统，对来自人类和食物的沙门氏菌菌株进行分子分型。预防建议应扩大到所有有诱发条件的危险群体
Listeriosis has been a mandatorily notifiable disease in Germany since January 2001. Clinical cases with isolation of Listeria monocytogenes from sterile specimens or neonates are reported to the Robert Koch-Institut. Listeriosis incidence significantly increased from 0.26 per 100 000 inhabitants (217 cases) in 2001 to 0.62 per 100 000 (519 cases) in 2005.Listeriosis has been a mandatorily notifiable disease in Germany since January 2001. Clinical cases with isolation of Listeria monocytogenes from sterile specimens or neonates are reported to the Robert Koch-Institut. Listeriosis incidence significantly increased from 0.26 per 100 000 inhabitants (217 cases) in 2001 to 0.62 per 100 000 (519 cases) in 2005. The increase only occurred among non pregnancy-associated cases and was mainly due to a rise in cases in the age group > or =60 years. The highest incidences were observed in neonates and adults > or =70 years. Male cases predominated, except for cases occurring in adults of child-bearing age. The overall case fatality rate was 9%. No temporal or spatial clusters of cases were observed and no outbreaks with a common source vehicle were identified. In 46% of the cases malignancies were reported as predisposing factor. Reasons for the increase of listeriosis in Germany remain unclear. The newly implemented surveillance system, and raised diagnostic awareness, cannot explain the particularly high increase in incidence from 2004 to 2005. Increased contamination of common foodstuffs or changes in underlying medical conditions or treatment options may have contributed to the increase. A project for enhanced listeriosis surveillance was begun in 2005 to obtain more detailed information about the clinical course, underlying conditions, medical treatment, knowledge about listeriosis and possible food risk factors from all newly diagnosed cases. For better outbreak detection, a nationwide system for molecular subtyping of listeria strains from humans and food is necessary. Recommendations for prevention should be extended to all risk groups with predisposing conditions