New insights into the role of HDL as an anti-inflammatory agent in the prevention of cardiovascular disease.
New insights into the role of HDL as an anti-inflammatory agent in the prevention of cardiovascular disease.
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DOI：
10.1007/bf02938394
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发表时间：
2007-11-01
影响因子：
3.7
通讯作者：
Rye, Kerry-Anne
中科院分区：
文献类型：
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作者：
Barter, Philip J;Puranik, Rajesh;Rye, Kerry-Anne
高密度脂蛋白（hdl）的一些已知功能可能有助于它们预防动脉粥样硬化的能力。这些功能中最著名的是促进胆固醇从细胞外排的能力，这一过程可能会最大限度地减少泡沫细胞在动脉壁的积累。然而，高密度脂蛋白具有其他特性，包括抗氧化、抗炎和抗血栓作用，也可能具有抗动脉粥样硬化的作用。最近在几种动物模型中的体内研究表明，hdl可以抑制急性和慢性血管炎症。事实上，这些效果可以通过非常低剂量的重组盘状高密度脂蛋白或甚至无脂载脂蛋白a - i来实现，这表明它们可能反映了少量高活性高密度脂蛋白亚群的活性。这些结果对于急性冠状动脉综合征和急性缺血性中风伴随的急性血管炎症状态的管理具有潜在的重要临床意义。
Several known functions of high-density lipoproteins (HDLs) may contribute to their ability to protect against atherosclerosis. The best known of these functions is the ability to promote cholesterol efflux from cells in a process that may minimize the accumulation of foam cells in the artery wall. However, HDLs have additional properties, including antioxidant, anti-inflammatory, and antithrombotic effects, that may also be anti-atherogenic. Recent in vivo studies in several animal models have demonstrated that HDLs can inhibit acute and chronic vascular inflammation. The fact that these effects can be achieved with very low doses of reconstituted discoidal HDL or even lipid-free apolipoprotein A-I suggests that they may reflect activity of a minor, highly active HDL subpopulation. These results have potentially important clinical implications in regard to managing the acute vascular inflammation states that accompany acute coronary syndrome and acute ischemic stroke.